Get the complete project »
- The Complete Research Material is averagely 52 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦7,000
A study on the assessment of Onchocercavolvulus infection in humans and blackflies and the onchocerciasis response to ivermectin therapy among some villagers around Gurara dam was conducted between June to November 2015. A total of 158 skin snips were collected and 4994 black flies were caught. The skin snips and female black flies were analysed by means of microscopy to detect Onchocerca volvulus. From the skin snips analysed, 4(2.6%) were positive for Onchocerca volvulus infection, The highest number of flies caught (1274) and highest number of parous flies (1089) were recorded in June. The highest number of infected flies, 14(38%) was obtained in the month of July. The amplified Polymerase Chain Reaction (PCR) detected O. volvulus DNA from skin snip of some individuals. The drug of choice, Ivermectin, administered in the study population was observed to be effective in humans, with 75% complete resolution of symptoms such as dermatitis and reduction in nodules. The highest incidence of Onchocerca volvulus was found among the age group of 50 years and above (75%). The prevalence was higher among the farmers (75%) with equal distribution among females (50%) and males (50%), followed by artisans (25%). The risk factor implicated was regular visit to the dam. The signs and symptoms of onchocerciasis observed in this study were; white patches, severe body itch, nodules and hanging groins. This study revealed that infective blackflies are still hovering around Gurara dam and vicinity, thus the persistence of onchocerciasis among the inhabitants, especially farmers, of the sampled villages. Hence the call for an effective vector control and a well supervised and prolonged ivermectin distribution is necessary.
Onchocerciasis or “river blindness” is a parasitic disease caused by the filarial
nematodeOnchocerca volvulus and transmitted by repeated bites of infected blackflies of
the Simulium species(WHO, 2013).
The adult filarial worms are usually found in subcutaneous nodules and have an average
longevity of around 9-11 years Tthe adult female worm produces millions of
microfilariae who migrate to the skin of the host (Marroquin, 1981).
The microfilariae are the main cause of the clinical manifestations of the disease
(Shibuya, 2006). Onchocerciasis is characterized by chronic skin disease, severe itching,
and eye lesions that can progress to complete blindness (CDC, 2013). It is endemic in
Nigeria (Evans etal., 2011). Onchocerciasis is the second leading cause of blindness
(after trachoma) in the world (Dent and Kazura, 2011).
The disease was highly endemic in many parts of the world before the commencement
of control activities, affecting millions of people in Africa, South and Central America,
and Yemen (Babalola, 2011). Approximately 123 million persons are at risk of
contracting onchocerciasis in 38 endemic countries with at least 25.7 million infected,
and about 1 million reported blinded or exhibiting severe visual impairment. Nigeria
accounts for one-third of these estimates (CDC, 2013).
Onchocerciasis is basically a rural disease affecting communities sited along fast-
flowing rivers with symptoms particularly irritating and disabling, often associated with
long-term exposure to infection and this affects the social and economic activities of the
inhabitants concerned (Okonkwo et al., 2010).
Both the savannah type that is associated with severe eye disorders and blindness and
the forest type which causes more skin damage are present and responsible for the
divergent clinic-epidemiologic picture. One of the major reasons northern Nigeria is
reported to have higher blindness rates than the southern part is owing to the widespread
distribution of savannah species of O. volvulus. In the south, the forest species that cause
mostly skin diseases abound (Okonkwo etal., 1991).
In Nigeria, most of the activities of the individuals in affected communities include
farming, fishing, handicraft and trading. Rural dwellers flee from this plague and
migrate to urban cities disrupting the socioeconomic development in their communities
(Alonso et al., 2009).
According to Ubachukwu (2006), one of the social consequences associated with
onchocerciaisis is the disruption of family life and relationships as disabled persons
desert rural villages to urban cities for better quality of life. However in the city, they are
unable to access and secure employment, and thus experience extreme poverty and
become beggars on the streets, they end up settling in shanty towns and resort to living
In addition, the burden of the disease impacts women and children, it affects the age of
marriage in young women, limiting their choice of partners such as older men and
divorcees. It also prevents infected mothers from practicing exclusive breastfeeding,
reducing bonding between new born and mother. The educational impact of the disease
is especially on children as they drop out from school to care for and lead blind family
members (Ubachukwu, 2006).
The vector (black fl
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
SIMILAR MICROBIOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
1. DESIGN AND IMPLEMENTATION OF AN EXPERT SYSTEM ON THYPHOID AND MALARIA DIAGNOSIS (A case study of Park Lane Hospital Enugu)» CHAPTER ONE INTRODUCTION 1.1 Background of the Study An expert system is a software system that attempts to reproduce the performance of one or more h...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION 1.1 Phytoremediation Phytoremediation is defined as the combined use of plants, soil amendments and agronomic practices t...Continue Reading »
3. SUSCEPTIBILITIES OF Salmonella typhi AND OTHER BACTERIAL PATHOGENS TO ANTIBIOTICS AND HOT AQUEOUS EXTRACT OF Hibiscus sabdariffa» ABSTRACT The susceptibilities of Salmonella typhi and other pathogens to antibiotics and hot aqueous extract of Hibiscus sabdariffa were investigated ...Continue Reading »
» ABSTRACT Water is one of the indispensable resources for the continued existence of all living things including man. The provision of an adequate supp...Continue Reading »
5. PREVALENCE OF MULTIDRUG RESISTANT LIVESTOCK ASSOCIATED STAPHYLOCOCCUS AUREUS ISOLATED FROM NASAL PASSAGE OF HEALTHY CATTLE IN KARA MARKET OGUN STATE N...» ABSTRACT Staphylococcus aureus, ‘one of the most adaptable and virulent pathogens in modern times’ is a facultative anaerobic Gram positiv...Continue Reading »
6. ANTITRYPANOSOMAL ACTIVITIES OF ACACIA NILOTICA AND KHAYA SENEGALENSIS AND THE HAEMATOLOGICAL PROFILE OF TRYPANOSOMA BRUCEI BRUCEI INFECTED WISTAR RATS» ABSTRACT This study was aimed at investigating antitrypanosomal activities and haematological profile of crude extract and fractions of the stem bark ...Continue Reading »
» ABSTRACT Onion is associated with micro organisms which are capable of causing spoilage. Onions with rots were examined microscopically. A solution of...Continue Reading »
8. PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY OF Acalypha wilkesiana EXTRACT AGAINST CLINICAL ISOLATES OF Candida albicans» ABSTRACT The increased, sustained interest in the production of plant based drugs for the treatment of many diseases has become a significant reason w...Continue Reading »
9. A PRACTICAL CARRIED OUT AT X-RAY DEPARTMENT, SHEHU MUHAMMAD KANGIWA MEDICAL CENTRE (S.M.K.M.C), KADUNA POLYTECHNIC, KADUNA STATE» ABSTRACT Diagnostic x ray is useful in detecting abnormalities within the body. They are a painless, non invasive way to help diagnose problems such a...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION: Nematodes are tiny, thread like worms measuring 0.0 15 inch to 0.187 inch in length. They are either free living parasit...Continue Reading »