Get the complete project »
- The Complete Research Material is averagely 50 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦4,000
The high prevalence, complications and cost of conventional drugs in the management diabetes necessitated the search for alternative treatment. As a result, this study seeks to evaluate the composition, anti-diabetic potential toxicity and tissue-protective effects of both the water and methanolic extracts of Persea americana (avocado pear) seed on alloxan-induced diabetic albino rats were investigated. This study was conceived and designed based on information on the local use of the seed in diabetes treatment. Proximate and anti-nutritional constituents of the seed were determined and 100g of the sample was extracted with 1000ml of both water and methanol using the maceration method. The extracts were evaporated to dryness using a rotary evaporator and stored at 4oC until use. The effects of different doses (200mg/kg.b.wt., 300/kg.b.wt.) of both water and methanolic extracts of P. americana seed on alloxan-induced diabetic albino rats were compared with those of a reference drug, insulin. The glucose level and weight of the rats were measured weekly for 21 days. The liver function tests and the histopathologies of the liver, and kidneys, were investigated. Results of the proximate investigation shows that the seed is rich in carbohydrate (49.03± 0.02 g/100g), lipid (17.90± 0.14 g/100g), protein (15.55± 0.36 g/100g) moisture (15.10± 0.14 g/100g) and ash (2.26±0.23 g/100g). Anti nutritional components such as total oxalate (14.98±0.03 mg/100g), tannin (6.98±0.04 mg/100g) and phytic acid (3.18±0.16 mg/1 00g). Results also showed that both the water and methanolic extracts exhibited significant anti-diabetic effects on the experimental rats. However, the methanolic extracts showed a better anti diabetic effect than the water extracts. The extracts showed no significant effects on the liver function parameters (bilirubin, conjugate bilirubin, AST, ALP and ALT) compared with the normal control but rather reversed the histopathological damage that occurred in alloxan-induced albino diabetic rats. In conclusion, the present study provides a pharmacological basis for the traditional use of P. americana seeds extracts in the management of Diabetes mellitus. It seems P. americana seed contains substantial amount of nutrients that could warrant its utilization in animal feed or food. However, further studies are required to indentify the active ingredient responsible for the anti-diabetic properties of the seed extract.
During the past decade, the traditional systems have gained importance in the field of medicine. The World Health Organization estimates that 4 billion people, 80% of the world population (WHO, 2002), presently use herbal medicine for some aspect of primary health care (Orisataoki and Oguntibeju, 2010). Eighty percent (80%) of African populations use some form of traditional herbal medicine (WHO, 2002.) and the worldwide annual market for these products approaches US$ 60 billion (Willcox and Bodeker, 2004). Herbal medicine is a major component in all indigenous people's traditional medicine. Medicinal plants have continued to attract attention in global search for effective methods of using plants parts (e.g. seeds, leaves, stems, roots, barks etc) for the treatment of many diseases affecting humans (Sofowora, 2008). This is as a result of the continuous need for less expensive means of disease control.
Medicinal plants are plants which can be used for therapeutic purposes or which are precursors for the synthesis of useful drugs (Sofowora, 2008). Many important drugs used in healthcare today are directly derived from plants due to its bioactive constituents such as; alkaloids, tannins, steroids, etc. Examples include L-Dopa derived fromMucuna spp used for anti-parkinsonism, another is Caffeine, a CNS stimulant derived from Camellia sinensis and Quinine from Cinchona ledgeriana and used for Antimalarial, antipyretic.
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
1. MODULATION OF HIGH FRUCTOSE FED, STREPTOZOTOCIN-INDUCED TYPE 2 DIABETES BY WONDERFUL KOLA (BUCHHOLZIA CORIACEA) SEED EXTRACTS IN MALE WISTAR RATS» ABSTRACT Type 2 diabetes (T2D) occurs when there is an advanced determent in insulin action (insulin resistance, IR), which proceeds toβ cell dys...Continue Reading »
2. INVESTIGATION OF THE PANCREATIC EFFECT OF BUCCHOLZIA CORICACEA FORMULATED DIET IN SUCROSE FED PREGNANT RATS AND THEIR OFFSPRING» ABSTRACT Several plants have been used in the treatment of various disorders without scientific basis. The present study examine the pancreatic effect...Continue Reading »
3. EFFECTS OF BITTER LEAF SOUP WITH GARRI ON BLOOD GLUCOSE AND GROWTH PERFORMANCES OF TYPE ONESTZ [STREPTOZOCIN] INDUCED DIABETIC RATS» ABSTRACT The effect of ethanolic leaf extract of Sphenocentrum jollyanum pierre (SPJ) on liver function and hematological indices of cadmium chloride ...Continue Reading »
4. EFFECT OF METHANOLIC LEAF EXTRACT OF ACALYPHA WILKESIANA ON WEIGHT PARAMETERS IN PARACETAMOL INDUCED HEPATOXICITY IN MALE WISTAR RATS RATS» ABSTRACT The potential effect of methanolic extract of the leaves of Acalypha wilkesiana on the weight of wistar rats was investigated. Calculated amo...Continue Reading »
5. EFFECT OF ETHANOLIC ROOT EXTRACT OF JATHROPHA TANJORENSIS ON KIDNEY FUNCTION OF FEMALE ALBINO WISTAR RATS» ABSTRACT Jatropha tanjorensis has been consumed as a leafy vegetable and as a medicinal plant in Nigeria has shown hematological, antimalarial, antimi...Continue Reading »
6. ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS.» ABSTRACT Anti hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root ba...Continue Reading »
7. ETHANOL LEAF EXTRACT OF Irvingia gabonensis O’Rorke Baill MITAGATES SODIUM ARSENITE-INDUCED NEPHROTOXICITY IN WISTAR ALBINO RATS» ABSTRACT The aim of this study was to investigate the effect of Irvingia gabonensis O’Rorke Baill ethanol leaf extract on kidney function in sodium ...Continue Reading »
8. COMPARATIVE STUDY OF THE EFFECT OF Rauwolfia vomitoria ROOT-BARK EXTRACT ON SEX HORMONES IN MALE AND FEMALEALBINO WISTAR RATS» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND OF STUDY Plants have been considered as sources of medicinal agents, as it offers natural products useful for ...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION Neem (Azadirachta indica A. Juss) is one of the very few trees known in the Indian subcontinent (Puri, 1999). This tree b...Continue Reading »
10. CONSUMPTION PATTERN AND EFFECT OF PROCESSING ON FATTY ACID PROFILE OF MILK FAT (MANSHANU) PRODUCED FROM MILK OF LOCAL COW BREEDS IN ZARIA» ABSTRACT The consumption pattern and effect of processing on fatty acid profile of milk fat (manshanu) produced from milk of local cow breeds (Bunaji,...Continue Reading »