Get the complete project »
- The Complete Research Material is averagely 31 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦4,000
Gout was described by Hippocrates as “the disease of kings” due to its association with rich diet. (Falasca, 2006). Gout is a heterogeneous group of diseases resulting from the deposition of urate (as monosodium urate monohydrate) crystals in supersaturated extracellular fluids. It’s also a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and swollen joint (Chen and Schumacher, 2008). Pain typically comes on rapidly in less than twelve hours (Richette and Bardin, 2010). The joint at the base of the big toe is affected in about half of cases (Schlesinger, 2010). It may also result in tophi, kidney stones, or urate nephropathy (Richette and Bardin, 2010).
Gout is due to persistently elevated levels of uric acid in the blood. This occurs due to a combination of diet and genetic factors (Richette and Bardin, 2010). At high levels, uric acid crystallizes and the crystals deposit in joints, tendons, and surrounding tissues, resulting in an attack of gout which may be first acute an then to chronic gouty arthritis. Nodular masses of monosodium urate crystals may be deposited in the soft tissues, resulting in chronic tophaceous gout. Gout occurs more commonly in those who regularly eat meat or seafood, drink beer, or are overweight (Beyl et al., 2016). Diagnosis of gout may be confirmed by the presence of crystals in the joint fluid or tophus. Blood uric acid levels may be normal during an attack (Richette and Bardin, 2010).
Gout affects about 1 to 2% of the Western population at some point in their lives. It has become more common in recent decades (Richette and Bardin, 2010). This is believed to be due to increasing risk factors in the population, such as metabolic syndrome, longer life expectancy, and changes in diet (Richette and Bardin, 2010). Older males are most commonly affected.
1.2 Signs and symptoms
Gout can present in multiple ways, although the most usual is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint) (Chen and Schumacher, 2008). The metatarsal-phalangeal joint at the base of the big toe is affected most often, accounting for half of cases (Schlesinger, 2010). Other joints, such as the heels, knees, wrists, and fingers, may also be affected (Schlesinger, 2010). Joint pain usually begins over 2–4 hours and during the night (Schlesinger, 2010). This is mainly due to lower body temperature (Eggebeen, 2007). Other symptoms which may rarely occur along with the joint pain include fatigue and a high fever (Eggebeen, 2007).
Long-standing elevated uric acid levels (hyperuricemia) may result in other symptoms, including hard, painless deposits of uric acid crystals known as tophi. Extensive tophi may lead to chronic arthritis due to bone erosion (Terkeltaub, 2010). Elevated levels of uric acid may also lead to crystals precipitating in the kidneys, resulting in stone formation and subsequent urate nephropathy (Tausche et al., 2009).
You either get what you want or your money back. T&C Apply
Share a Comment
You can find more project topics easily, just search
SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
1. EFFECT OF ETHANOLIC ROOT EXTRACT OF JATHROPHA TANJORENSIS ON KIDNEY FUNCTION OF FEMALE ALBINO WISTAR RATS» ABSTRACT Jatropha tanjorensis has been consumed as a leafy vegetable and as a medicinal plant in Nigeria has shown hematological, antimalarial, antimi...Continue Reading »
52 pages | 217 hits | Source: BIOCHEMISTRY
» CHAPTER ONE INTRODUCTION 1.1. BACKGROUND INFORMATION Selenium (Se) is an essential trace element having biological functions of utmost importance for ...Continue Reading »
45 pages | 164 hits | Source: BIOCHEMISTRY
3. ANTIMICROBIAL AND PHYTOCHEMICAL PROPERTIES OF YOUNGCOCOS NUCIFERA (COCONUT) WATER AND METHALONIC EDXTRACT OF THE YOUNGCOCOS NUCI» CHAPTER ONE 1.0 INTRODUCTION AND LITERATURE REVIEW 1.1 INTRODUCTION Medicinal plants represent a rich source of antimicrobials and many other drugs. T...Continue Reading »
52 pages | 235 hits | Source: BIOCHEMISTRY
4. EFFECTS OF DIFFERENT TYPES OF ORGANIC FERTILIZERS ON GROWTH PERFORMANCE, NUTRIENTS AND TOXICOLOGICAL COMPOSITION OF AMARANTHUS CAUDATUS AND AMARANTHUS...» Abstract The objective of this study is to evaluate the effect of different types organic fertilizers on growth performance, nutrient and toxicologica...Continue Reading »
152 pages | 79 hits | Source: BIOCHEMISTRY
5. EVALUATION OF NUTRITIVE AND NON-NUTRITIVE COMPONENTS AND ANTI-DIABETIC PROPERTIES OF EDIBLE PORTIONS OF Chrysophyllum albidum FRUIT IN STREPTOZOTOCIN-...» CHAPTER ONE INTRODUCTION 1.1 Background to the Study Dietary control is vital in the management of diabetes. Reports from FAO (1998); WHO and FAO (200...Continue Reading »
225 pages | 120 hits | Source: BIOCHEMISTRY
6. COMPARATIVE STUDY OF THE EFFECT OF Rauwolfia vomitoria ROOT-BARK EXTRACT ON SEX HORMONES IN MALE AND FEMALEALBINO WISTAR RATS» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND OF STUDY Plants have been considered as sources of medicinal agents, as it offers natural products useful for ...Continue Reading »
60 pages | 189 hits | Source: BIOCHEMISTRY
7. ETHANOL LEAF EXTRACT OF Irvingia gabonensis O’Rorke Baill MITIGATES SODIUM ARSENITE-INDUCED LIPID PROFILE DERANGEMENTS IN WISTAR RATS» ABSTRACT The effect of ethanol leaf extract of Irvingia gabonensis O’Rorke Baill on lipid profile in sodium arsenite exposed Wistar albino rats was ...Continue Reading »
52 pages | 162 hits | Source: BIOCHEMISTRY
8. DIFFERENTIAL EXPRESSION LEVELS OF GLUTATHIONE-S-TRANSFERASE (OvGST1) GENE IN THE HOST (HUMAN) AND VECTOR Simulium damnosum» Abstract Onchocerciasis, a neglected tropical disease (NTD), also known as river blindness, the world‟s second leading cause of preventable blindnes...Continue Reading »
52 pages | 23 hits | Source: BIOCHEMISTRY
» CHAPTER ONE 1.0 INTRODUCTION Seed and coat of Mucuna pruriens, known as velvet beans or cowitch has scientific classification as shown below; Kingdom ...Continue Reading »
52 pages | 494 hits | Source: BIOCHEMISTRY
» CHAPTER ONE 1.0 INTRODUCTION Neem (Azadirachta indica A. Juss) is one of the very few trees known in the Indian subcontinent (Puri, 1999). This tree b...Continue Reading »
52 pages | 401 hits | Source: BIOCHEMISTRY