THE EFFECT OF ORAL INGESTION OF FUSARIUM OXYSPORUM INOCULATED SORGHUM ON THE HISTOLOGY OF KIDNEY AND LIVER OF ADULT WISTAR RATS (RATTUS NOVEGICUS)

THE EFFECT OF ORAL INGESTION OF FUSARIUM OXYSPORUM INOCULATED SORGHUM ON THE HISTOLOGY OF KIDNEY AND LIVER OF ADULT WISTAR RATS (RATTUS NOVEGICUS)

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ABSTRACT

Fusarium oxysporum is an important pathogen of a wide range of

crop plants. The study was conducted to investigate the effect of

feeding a blend of sorghum grains contaminated with Fusarium

oxysporum on the blood picture and the histology of the kidney and

liver of adult wistar rats. A total of thirty (30) rats of the wistar

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species weighing between 150 and 180g were divided into four

experimental groups and a control group comprising six(6) rats in

each group and fed for twenty eight days(28).The diet consisted

control(group       1),25%       contaminated       meal(group       2),50%

contaminated(group 3),75% contaminated(group 4) and 100%

contaminated meals(group 5).

At the end of the experiment the RBC, WBC and differential

WBC counts did not show any significant differences (P 0.05).the

histological studies however showed damage to the kidney tissue

under light microscopy. They were characterized by degraded renal

tubules, necrosis of glomerular cells, and apoptotic bodies in areas

between the renal tubules infiltrated by mononuclear cells.

The liver histology showed by light microscopy, loss of hepatic

architecture, pyknotic nuclei and infiltration by mononuclear cells.

It was therefore concluded that Fusarium oxysporum has caused

marked inflammation and tubular necrosis in the rat’s kidney as

well as inflammation and parenchymal necrosis in the liver with no

significant changes in the blood picture.

CHAPTER ONE

1.1                                     


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