THE EFFECT OF ORAL ADMINISRATION OF Pausinystalia yohimbe ON THE HAEMATOLOGICAL PARAMETERS AND HISTOLOGY OF THE HYPOTHALAMUS OF ADULT MALE WISTAR RATS

THE EFFECT OF ORAL ADMINISRATION OF Pausinystalia yohimbe ON THE HAEMATOLOGICAL PARAMETERS AND HISTOLOGY OF THE HYPOTHALAMUS OF ADULT MALE WISTAR RATS

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ABSTRACT

The bark of the West African Pausinystalia yohimbe tree is a traditional aphrodisiac and

the source of yohimbine, a prescription drug for impotence. It appears to be modestly

effective, but it also presents numerous safety risks. The possible side effect on the

haematological parameters and histology of the hypothalamus has not been considered.

This study investigated experimentally using adult male Wistar rats, the changes in

haematological parameters and the histology of the hypothalamus due to oral

administration of the crude extract Pausinystalia yohimbe bark.

Thirty six (36) adult male Wistar rats of average weight of 200g, used for this

experiment. The animals were grouped into four (4) groups of nine (9) animals per group.

With group I serving as the control and administered distilled water. While group II, III

and IV administered 30mg/kg, 50mg/kg and 100mg/kg body weight per day of the crude

extract of Pausinystalia yohimbe bark orally respectively, for three (3) weeks.

Blood samples were collected from all the animals for the haematological studies and the

brain tissues were also collected and fixed in Bouin’s fluid and processed for histological

studies using the method of Glee’s. The photomicrographs of the tissues were taken using

an Optical Eye Piece connected to a computer system. The results showed that the

Pausinystalia yohimbe bark extract produced significant increased in the erythrocytes

count values, total protein and clothing time decrease in the leukocyte count, monocyte

and eosinophils differential counts. The extract also has excitatory effect on the nuclei of

the hypothalamus, indicating cellular hyperplasia.

CHAPTER ONE

1.0       INTRODUCTION

Presently, there is a growing interest in the use of natural products. Various

products of plant origin are being marketed in Nigeria.     They range from herbal

toothpastes to various drug supplements. Some of these herbal preparations may have

some inherent properties, which have contributed to their persistent use over the yea


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