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Toxins such as drugs, chemicals, endocrine disruptors, biogenetically engineered western diets
and life style among other factors are known to affect normal body functions and most especially
reproductive health (Izegbu et al., 2005). One of such toxins (Drugs) which posses adverse
health hazard despite it`s advantages is Ketoconazole an antifungal drug used in the treatment of
fungal infections such as blastomycosis, histoplasmosis, coccidioidomycosis and para
coccidioidomycosis (Amir, 2008).
Ketoconazole is packaged pharmaceutically in the form of tablets, Creams and injection and has
been reported to inhibit the stimulation of testicular testosterone production by Human Chorionic
Gonadotropine in a dose dependent manner (Richard et al., 2005). Steroids such as
dihydrotestosterone and estradiol are equally, selectively displaced from serum-binding globulin
by ketokonazole (Grosso et al., 2005). The suppression of testicular testosterone synthesis and
displacement of oestrogen from sex hormone binding globulin may decrease the
androgen/oestrogen ration of the blood and contributes to the development of gynaecomastia that
has being reported in some ketoconazole treated patients (Boyden et al., 2005).Administration of
ketoconazole alters sperm indices and causes severe histopathological lesion such as depletion of
germ cells, degeneration of the seminiferous tubules, marked oxidative damage to testicular
lipids and alteration of natural anti oxidants(Amin,2008).
Over the years, there has being increased scientific research to minimize the health hazards
potentiated by some toxin and this was done on phytochemical being extracted from plant
species (Bankole et al., 2007). In an effort to stem the contraindications of some of these
synthesized drugs, Plant medicine (phyto-medicine) has being used as alternatives in many parts
of Africa and the rest of the world (Elujoba et al., 2005).
Effective health cannot be achieved in Africa, unless orthodox medicine is complemented with
traditional medicine (Elujoba et al., 2005).At least 80% of Africans depends on plant medicine
for their health care (Sofowora, 1993).Fruit and vegetables have being recognized as natural
source of various bioactive compounds (Penington and Fisher, 2010). The bioactive property of
fruits and vegetables could be attributed to their phyto-constituents such as flavanoids,
anthocyanins, vitamins C and E, phenolic compounds, dietary fiber and carotinoids (Gonz,
Aguilar, et al., 2008).One of such vegetable plant is Sesame indicum whose taxonomic Order is
lamiales, Family is pedialiaceae, Genus is sesamum and Specie is indicum. Sesame seeds exist
in brown, black and yellow forms and are called ‟ ridi” in Hausa, ‟ Ekuku” in Yoruba, ‟ Isasa”
in Ibo and ‟ go-ri-go” in Ebira languages.
Sesame seed has being reported to contain high level of unsaturated fatty acids which are Oleic
acid-38.84%, linolenic acid-46.26 % (Nzioku et al., 2009). Trace elements such as Calcium,
Iron, Magnesium, Zinc, Copper and Phosphorous are also reported to be contained in it
(Obiajunwa et al., 2005). Sesame seed is also reported to be rich in phyto estrogenic lignans
which is an important phytochemical known to man (Thompson et al., 1991).
Sesame seed oil has being used as a healing oil for thousands of years it naturally posses
antibacterial property for common skin pathogen such as staphylococcus and streptococcus it
also posses anti fungal, antiviral and anti inflammatory effects (Amir, 2008). The entire sesame
plant are very valuable and serve as staple food in most ethnic groups in north central and south
western part of Nigeria and this may be attributed to the high level of fecundity among adult
males in these regions (Akpan et al .,2006).
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SIMILAR ANATOMY FINAL YEAR PROJECT RESEARCH TOPICS
1. HISTOLOGICAL ASSESSMENT OF THE TESTES AND HORMONAL PROFILE OF ADULT MALE ALBINO WISTAR RATS FOLLOWING ORAL ADMINISTRATION OF MYRISTICA FRAGRANS (NUTM...» ABSTRACT The study was carried out to assess the effect of oral administration of Myristica fragrans (Nutmeg) on the histology of the testis as well a...Continue Reading »
» ABSTRACT In the last five decades, genetic structure of populations are being studied in via ABO blood groups system, mtDNA and Y chromosome makers to...Continue Reading »
3. EVALUATION OF THE ANTIDIARRHOEAL EFFECT OF AQUEOUS FRUIT EXTRACT OF Phoenix dactylifera L. ON THE HISTOLOGY OF THE SMALL INTESTINE OF WISTAR RAT» ABSTRACT In this study, evaluation of the antidiarrhoeal effect of aqueous fruit extract of Phoenix dactylifera L. on the histology of the small intes...Continue Reading »
4. ANTHROPOMETRIC COMPARISM OF CEPHALIC INDICES BETWEEN YORUBA AND BENIN ETHNIC GROUPS RESIDING IN OKADA TOWN, EDO STATE.» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND OF STUDY Anthropometry (from Greek anthropos, "man" andmetron, "measure") refers to the measurement of the hum...Continue Reading »
5. EVALUATION OF SECOND AND FOURTH DIGIT RATIO, ANTHROPOMETRIC PARAMETERS AND AGGRESSION AMONG STARTISANS AND NON-ARTISANS IN ZARIA, KADUNA STATE, NIGERI...» ABSTRACT A growing body of literature, has associated exposure to prenatal testosterone, to the length second to fourth digit ratios (2D:4D) and this ...Continue Reading »
6. DISTRIBUTION OF ABO AND RH (D) BLOOD GROUPS AND ASSOCIATED TRAITS: A STUDY OF THE COLLEGE OF NURSING AND MIDWIFERY, OBANGEDE, KOGI STATE» ABSTRACT In the last five decades, genetic structure of populations are being studied in via ABO blood groups system, mtDNA and Y chromosome makers to...Continue Reading »
7. RELATIONSHIP BETWEEN SOMATOTYPES AND HEPATOBILIARY DIMENSIONS, BODY COMPOSITION, AND SOME ANTHROPOMETRIC VARIABLES OF STUDENTS IN AHMADU BELLO UNIVERS...» ABSTRACT Previous studies have suggested an association of somatotype with body composition and the organ dimensions among individuals and populations...Continue Reading »
8. PROSPECTIVE AND RETROSPECTIVE STUDY OF SOME ANTHROPOMETRIC AND REPRODUCTIVE CHARACTERISTICS OF GRAVID AND MENOPAUSAL NIGERIAN WOMEN.» ABSTRACT This study investigated some anthropometric and reproductive characteristics associated with nausea and vomiting of pregnancy (NVP) and menop...Continue Reading »
» ABSTRACT The study of the effect of oral administration of aluminium chloride on the Hippocampus of wistar rats was carried out in order to ascertain ...Continue Reading »
10. Anthropometric Study and Stature Estimation in Lokaa, Ayiga, Agoi and Ekoi Ethnic Groups of Yakurr Local Government Area of Cross River State, Nigeria» ABSTRACT Stature prediction occupies relatively a central position in anthropometric research. Estimation of stature of an individual from the mutilat...Continue Reading »