Get the complete project »
- The Complete Research Material is averagely 112 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦7,000
Multi-drug resistant tuberculosis (MDR-TB) remains a major challenge for the control of
tuberculosis worldwide. Susceptibility testing of Mycobacterium tuberculosis isolates to first line drugs is therefore necessary to ascertain the diagnosis of MDR-TB. A total of 437 re-treatment patients’ samples were screened for Acid Fast Bacilli (AFB), 72 were smear positive giving a prevalence of 16.47%. Out of 72 smears positive, 62 were culture positive, 6 were culture negative and 4 were contaminant using Lowenstein Jensen medium. Out of 62 cultures positive, 57 were found to be Mycobacterium tuberculosis complex (MTBC) using immunochromatographic test while 5 were negative which were considered to be NTM (Non-Tuberculosis Mycobacteria). In this study the susceptibility of 57 MTBC isolates to isoniazid (INH), rifampicin (RIF), streptomycin (STR) and Ethambutol (EMB) was determined by Lowenstein Jensen proportion method (LJPM) and Nitrate Reductase Assay (NRA). LJ PM detected 41(71.93%) MDR-TB while NRA detected 44(77.19%) MDR-TB isolates. The occurrence of poly resistance to anti-TB drugs using NRA and LJ PM was 12% and 14% while pan susceptible were of 11% and 14% by LJ PM and NRA respectively. The sensitivities and specificities of NRA compared to those of LJPM were observed to be 98% and 98%, 64% and 68%, 89% and 92%, 80% and 77% for RIF, INH, STR, and EMB respectively. Positive predictive values were 91%, 93%, 87% and 83% for RIF, INH, STR and EMB respectively. Negative values were 80%, 92%, 67% and 90% for RIF, INH, STR and EMB respectively. Good agreement was found in all the tests with κ values of 0.63, 0.61, 0.59, and 0.61for RIF, INH, STR, and EMB respectively. The HIV/TB co-infections and HIV/MDR-TB co-infections were reported to be 9.7% and 7% respectively. Highest MDR-TB among age groups of 21-30 and 31-40 years were detected by NRA and LJPM and higher MDR-TB and TB were observed in male. The NRA has the potential to be a useful tool for rapid detection of MDR-TB in resource-limited settings because of its higher sensitivity and specificity.
1.1 Background of the Study
Tuberculosis (TB) continues to cause more deaths worldwide than any other infectious disease.
The World Health Organization (WHO) estimated that in 2011, there were 8.7 million cases of
TB, with nearly 1 million deaths among HIV-negative cases and 0.43 million deaths associated
with HIV infection (WHO, 2012). More than 99% of deaths and 95% of new TB cases occur in
middle- and low-income countries (Palomino, 2012). In the 2012 Global Tuberculosis Report
estimates, expressed in rates per 100,000 populations, were 161 (25-420) for prevalence and 108
(50-186) for incidence. Case detection of all forms stood at 51% (29%-110%). The mortality rate
for all forms of TB remains 27 (7-60) per 100,000 populations (46,000 deaths per year) (WHO,
2012). The majority of TB cases worldwide were in the South-East Asia (29%), African (27%)
and Western Pacific (19%) regions. India and China alone accounted for 26% and 12% of total
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
SIMILAR MICROBIOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
1. A SURVEY OF MALARIA VECTORS AND PARASITES IN AGUOWA COMMUNITY, ENUGU - EAST LOCAL GOVERNMENT AREA, ENUGU STATE, SOUTH EASTERN NIGERIA» ABSTRACT The study set out to determine the presence of mosquito vectors of malaria, prevalent Plasmodium species as well as some blood parameters rel...Continue Reading »
2. DETERMINING THE POTENTIALS OF LACTIC ACID BACTERIA ISOLATED FROM NONO FOR USE AS STARTER CULTURES IN YOGHURT PRODUCTION» ABSTRACT This study was aimed at isolating, characterizing and optimizing lactic acid bacteria from „nono‟ for use as starter culture in yoghu...Continue Reading »
3. COMPARATIVE TOXICITY OF CRUDE OIL AND KEROSENE ON THE GROWTH OF NITRIFYING BACTERIA ISOLATED FROM SOIL» ABSTRACTCrude oil and kerosene have useful applications in the society and are, therefore, used as sources of income and energy. However, the spills a...Continue Reading »
4. EFFICACY OF ARTESUNATE IN THE TREATMENT OF URINARY SCHISTOSOMIASIS AT UMUIKWU- ANAM COMMUNITY IN ANAMBRA WEST LOCAL GOVERNMENT AREA OF ANAMBRA STATE, ...» ABSTRACT A study on the efficacy of artesunate in the treatment of urinary schistosomiasis at Umuikwu Anam community, Anambra West Local Government ar...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION The ultimate aim of scientific investigation about plants is to make active ingredients which are very useful in producti...Continue Reading »
6. MULTIDRUG RESISTANCE PROFILE AND METALLO-BETA-LACTAMASE PRODUCTION IN Pseudomonas aeruginosa ISOLATED FROM THE NASAL CAVITY OF CATTLE FROM KARA MARKET...» ABSTRACT Pseudomonas aeruginosa is an ubiquitous, Gram negative, rod shaped, monoflagellated bacterium, capable of causing serious infections in immun...Continue Reading »
7. DESIGN AND IMPLEMENTATION OF AN EXPERT SYSTEM ON THYPHOID AND MALARIA DIAGNOSIS (A case study of Park Lane Hospital Enugu)» CHAPTER ONE INTRODUCTION 1.1 Background of the Study An expert system is a software system that attempts to reproduce the performance of one or more h...Continue Reading »
» ABSTRACT Moringa Oleifera seed and leaves and other parts of the plants used in Eastern Nigeria have an impressive range of multipurpose medicinal use...Continue Reading »
» TABLE OF CONTENTS Chapter Title Pages Cover page Title Page Declaration Certification Dedication Acknowledgement Abstract Table of Contents List of Ta...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION Newcastle disease (ND) is one of the most important avian viral diseases because of its high economic impact on the poult...Continue Reading »