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Acquired immunodeficiency syndrome (AIDS) is a spectrum of disease states
characterised by progressive immunosuppression. It results from infection with
Human Immunodeficiency Virus (HIV) which is capable of affecting every
organ system in the body. Renal complications are important component of
advanced HIV disease, and these complications significantly contribute to
morbidity and mortality in these patients. Therefore regular assessment of their
renal status using sensitive markers such as Creatinine Clearance (CrCl)
together with serum electrolytes, creatinine, urea and uric acid is necessary.
The objective of this study was therefore to assess the renal function, determine
the appropriate assessment parameters and the prevalence of renal disease
among HIV/AIDS patients on highly active antiretroviral therapy (HAART) in
ABUTH, Zaria. Renal function of 101 HIV positive patients on HAART and
100 controls was assessed. The data obtained were analysed using statistical
programme for the social sciences 11.0 (SPSS 11.0).Two-tailed student׳s t-test
for matched samples and Pearson’s linear correlation statistical methods were
employed for the analysis. A p-value of equal to or less than 0.05 (p≤ 0.05) was
considered as statistically significant.
Mean levels of Na+, K+, HCO3-, Cl-, Ca2+ and PO42- obtained in patients were 138.97±0.43, 3.83±0.05, 25.28±0.26, 100.02±0.42, 2.62±0.03 and 1.21±0.03 mmol/L respectively, whereas the corresponding values in controls were 138.84±0.26, 3.96±0.04, 25.78±0.16, 98.90±0.35, 2.31±0.02 and 1.22±0.02 mmol/L respectively. These results showed that K+ was significantly lower (p< 0.05) while C
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