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Abstract
The concurrent use of herbal drugs and orthodox medicines for the treatment of various health
conditions is a common practice amongst patients; a practice that could result in drug-herb
interaction. This study evaluates the effects of Hibiscus sabdariffawater extract on thein vitro
and in vivo availability, as well as pharmacokinetics of metforminand lisinopril in healthy
human volunteers.For the determination of metformin and lisinopril in vitroin simulated
physiological pHs(0.1 M HCl, phosphate buffers pH of 6.8 and 7.4), three simples UV
spectrophotometric methodswere developed and validated according to ICH guidelines. The
in vitroavailability of metformin and lisinopril alone and in presence of Hibiscus sabdariffa
calyxes water extracts (1 g/L) in each of the three media(1 L and 900 mL) were
determinedusing dissolution apparatus (BP, 2013) set at 100and 50 rpm at 37 °C. Samples (5
mL) withdrawn from the media at 5, 10, 15, 30, 45, and 60 min were analysed for the
metformin and lisinopril content released using the appropriate developed method. For the
quantification of metformin and lisinopril in the in vivostudy, a RP-HPLC method was
developed and validated for each drug using caffeine as internal standard IS.The optimized
conditions comprise of a Chemsl ODS®C18 column (200 x 4.6 mm), binary mobile phase
(Methanol: Water 80:20)containing 0.1 % orthophosphoric acid as additive, isocratic elution
mode, 232 and 218 nm detection wavelengths flow rate of 1.0 mL/min and 10 µL injection
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SIMILAR PHARMACOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
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1. PHARMACOGNOSTIC PARAMETERS OF THE LEAVES OF BREONADIA SALICINA (RUBIACEAE)
» CHAPTER ONE 1.0: INTRODUCTION 1.1: PHARMACOGNOSY A GENERAL OVERVIEW Pharmacognosy, the modern science of natural medicines, is based on traditional me...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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2. KNOWLEDGE AND PRACTICE OF INFECTION CONTROL AMONG MIDWIVES IN LABOUR WARDS OF MAIDUGURI
» CHAPTER 1 INTRODUCTION 1.1 BACKGROUND Infection related diseases are still the main cause of death in Nigeria, according to the 2013 health profile ac...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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3. FACTORS INFLUENCING UTILIZATION OF PREVENTION OF MOTHER TO CHILD TRANSMISSION(PMTCT) SERVICE AMONG PREGNANT WOMEN ATTENDING ANTI-NATAL CLINIC IN UNIVE...
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4. THE KNOWLEDGE AND PRACTICE OF CONTRACEPTION AMONG FEMALE STUDENTS IN DELTA STATE UNIVERSITY, ABRAKA
» ABSTRACT INTRODUCTION: Contraceptives are drugs or device used to prevent a woman from being pregnant and also used to protect men and women from sexu...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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5. BACTERIOLOGICAL ANALYSIS OF WATER IN HALLS OF RESIDENCE IN UNIVERSITY OF BENIN
» CHAPTER ONE 1.0 INTRODUCTION Water is indispensable and intricately connected to life, without which there is no life. This is the reason for which wa...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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6. AVAILABILTY AND STORAGE OF VACINES IN COMMUNITY PHARMACIES
» CHAPTER ONE INTRODUCTION 1.0 Background of the Study Immunization is the process by which an individual’s immune system becomes fortified agains...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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7. PREVALENCE OF SCHISTOSOMA HEMATOBIUM INFECTION (SCHISTOSOMIASIS) AMONG THE CHILDREN ATTENDING L.G.E.A PRIMARY SCHOOL KAWO, KADUNA STATE
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8. PRODUCTION AND CHEMICAL QUALITY ASSESSMENT OF ASPIRIN
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9. ANTIOXIEANT ACTIVITY OF SEED EXTRACT AND FRACTIONS OF Monodora tsnuifolia (Annonaceae)
» ABSTRACT The antioxidant activity of the seed extract and fractions of Monodora tenuifolia (Fam. Annonaceae) was evaluated. The Monodora tenuifolia se...Continue Reading »Item Type & Format: Project Material - Ms Word | 101 pages |
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10. ACADEMIC FACTORS AFFECTING LEARNING AT A NURSING COLLEGE IN THE WESTERN CAPE
» ABSTRACT Nursing education, including the individual nurse educator, has a responsibility to society and to students for providing quality education, ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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