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Abstract
The concurrent use of herbal drugs and orthodox medicines for the treatment of various health
conditions is a common practice amongst patients; a practice that could result in drug-herb
interaction. This study evaluates the effects of Hibiscus sabdariffawater extract on thein vitro
and in vivo availability, as well as pharmacokinetics of metforminand lisinopril in healthy
human volunteers.For the determination of metformin and lisinopril in vitroin simulated
physiological pHs(0.1 M HCl, phosphate buffers pH of 6.8 and 7.4), three simples UV
spectrophotometric methodswere developed and validated according to ICH guidelines. The
in vitroavailability of metformin and lisinopril alone and in presence of Hibiscus sabdariffa
calyxes water extracts (1 g/L) in each of the three media(1 L and 900 mL) were
determinedusing dissolution apparatus (BP, 2013) set at 100and 50 rpm at 37 °C. Samples (5
mL) withdrawn from the media at 5, 10, 15, 30, 45, and 60 min were analysed for the
metformin and lisinopril content released using the appropriate developed method. For the
quantification of metformin and lisinopril in the in vivostudy, a RP-HPLC method was
developed and validated for each drug using caffeine as internal standard IS.The optimized
conditions comprise of a Chemsl ODS®C18 column (200 x 4.6 mm), binary mobile phase
(Methanol: Water 80:20)containing 0.1 % orthophosphoric acid as additive, isocratic elution
mode, 232 and 218 nm detection wavelengths flow rate of 1.0 mL/min and 10 µL injection
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SIMILAR PHARMACOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
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1. BACTERIOLOGICAL ANALYSIS OF WATER IN HALLS OF RESIDENCE IN UNIVERSITY OF BENIN
» CHAPTER ONE 1.0 INTRODUCTION Water is indispensable and intricately connected to life, without which there is no life. This is the reason for which wa...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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2. FACTORS INFLUENCING UTILIZATION OF PREVENTION OF MOTHER TO CHILD TRANSMISSION(PMTCT) SERVICE AMONG PREGNANT WOMEN ATTENDING ANTI-NATAL CLINIC IN UNIVE...
» CHAPTER ONE Introduction Background to the Study Everyday, approximately 5,000 women are newly infected with HIV (Human Immunodeficiency Virus), and m...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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3. Evaluation of Phyto-Chemical and Medicinal Properties of Cannabis sativa Linn. (Family: Moraceae).
» Abstract This work studied the various delivery systems (oral and parental formulations) of crude Cannabis. The stability, pharmacological and toxicol...Continue Reading »Item Type & Format: Project Material - Ms Word | 222 pages |
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4. COMPARATIVE PHYTOCHEMICAL ANALYSES OF METHANOLIC AND AQUEOUS LEAF EXTRACTS OF MEDICINAL PLANTS USED IN PLANT DISEASE CONTROL
» ABSTRACT: The aim of this research is to comparatively study the phytochemical and antimicrobial properties of Bryophyllum pinnatum and Citrus auranti...Continue Reading »Item Type & Format: Project Material - Ms Word | 61 pages |
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5. ANTIOXIEANT ACTIVITY OF SEED EXTRACT AND FRACTIONS OF Monodora tsnuifolia (Annonaceae)
» ABSTRACT The antioxidant activity of the seed extract and fractions of Monodora tenuifolia (Fam. Annonaceae) was evaluated. The Monodora tenuifolia se...Continue Reading »Item Type & Format: Project Material - Ms Word | 101 pages |
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6. AWARENESS, ATTITUDE AND PRACTICE OF HEALTH CARE PROFESSIONALS TO ADVERSE DRUG REACTION REPORTING IN NNEWI NORTH L.G.A, ANAMBRA STATE.
» ABSTRACT This descriptive cross sectional survey was conducted on healthcare professionals working at different healthcare facilities in Nnewi North L...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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7. NATURAL FAMILY PLANNING METHOD
» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND INFORMATION In the early days, human societies had creation of as many children as possible, a central value. ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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8. PHARMACOGNOSTIC PARAMETERS OF THE LEAVES OF BREONADIA SALICINA (RUBIACEAE)
» CHAPTER ONE 1.0: INTRODUCTION 1.1: PHARMACOGNOSY A GENERAL OVERVIEW Pharmacognosy, the modern science of natural medicines, is based on traditional me...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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9. CAUSES, MANAGEMENT AND PERCEPTION OF BREAST CANCER AMONG FEMALE STUDENTS( CASE STUDY; FACULTY OF SOCIAL SCIENCE IN DELTA STATE UNIVERSITY,ABRAKA, DELT...
» CHAPTER ONE INTRODUCTION BACKGROUND OF STUDY Breast cancer is the most common type of cancer in females and the leading cause of cancer morbidity and ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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10. THE WHOLISTIC NATURE OF AFRICAN TRADITIONAL MEDICINE: A CALL FOR SYNERGY WITH ORTHODOX MEDICINE
» CHAPTER ONE INTRODUCTION 1.1 Background of Study African traditional medicine is a medicine that is embedded in the religion of the people. In traditi...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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