- The Complete Research Material is averagely 152 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: MTech, MSc or PhD.
- Full Access Fee: ₦8,000
Get the complete project »

Abstract
The concurrent use of herbal drugs and orthodox medicines for the treatment of various health
conditions is a common practice amongst patients; a practice that could result in drug-herb
interaction. This study evaluates the effects of Hibiscus sabdariffawater extract on thein vitro
and in vivo availability, as well as pharmacokinetics of metforminand lisinopril in healthy
human volunteers.For the determination of metformin and lisinopril in vitroin simulated
physiological pHs(0.1 M HCl, phosphate buffers pH of 6.8 and 7.4), three simples UV
spectrophotometric methodswere developed and validated according to ICH guidelines. The
in vitroavailability of metformin and lisinopril alone and in presence of Hibiscus sabdariffa
calyxes water extracts (1 g/L) in each of the three media(1 L and 900 mL) were
determinedusing dissolution apparatus (BP, 2013) set at 100and 50 rpm at 37 °C. Samples (5
mL) withdrawn from the media at 5, 10, 15, 30, 45, and 60 min were analysed for the
metformin and lisinopril content released using the appropriate developed method. For the
quantification of metformin and lisinopril in the in vivostudy, a RP-HPLC method was
developed and validated for each drug using caffeine as internal standard IS.The optimized
conditions comprise of a Chemsl ODS®C18 column (200 x 4.6 mm), binary mobile phase
(Methanol: Water 80:20)containing 0.1 % orthophosphoric acid as additive, isocratic elution
mode, 232 and 218 nm detection wavelengths flow rate of 1.0 mL/min and 10 µL injection
You either get what you want or your money back. T&C Apply

You can find more project topics easily, just search
-
SIMILAR PHARMACOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
-
1. Evaluation of Phyto-Chemical and Medicinal Properties of Cannabis sativa Linn. (Family: Moraceae).
» Abstract This work studied the various delivery systems (oral and parental formulations) of crude Cannabis. The stability, pharmacological and toxicol...Continue Reading »Item Type & Format: Project Material - Ms Word | 222 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
2. INVESTIGATION OF THE BACTERIA ASSOCIATED WITH URINARY TRACT INFECT IN PREGNANT WOMEN
» ABSTRACT The aim of this study was to determine the The Bacteria Associated With Urinary Tract Infect In Pregnant Women In University Of Uyo Teaching ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
3. BACTERIOLOGICAL ANALYSIS OF WATER IN HALLS OF RESIDENCE IN UNIVERSITY OF BENIN
» CHAPTER ONE 1.0 INTRODUCTION Water is indispensable and intricately connected to life, without which there is no life. This is the reason for which wa...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
4. AVAILABILTY AND STORAGE OF VACINES IN COMMUNITY PHARMACIES
» CHAPTER ONE INTRODUCTION 1.0 Background of the Study Immunization is the process by which an individual’s immune system becomes fortified agains...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
5. ENUMERATON AND IDENTIFICATION OF BACTERIA ON USED HANDKERCHIEFS IN MALES
» ABSTRACT The enumeration, identification and characterization of bacteria on used handkerchiefs in males was carried out. A total of forty (40) handke...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
6. PRODUCTION AND CHEMICAL QUALITY ASSESSMENT OF ASPIRIN
» ABSTRACT The question on whether aspirin has any important role to play or not has generated a lot of controversies over years especially among the in...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
7. FEATURES, MANAGEMENT AND COST OF ILLNESS OF EPILEPSY IN AHMADU BELLO UNIVERSITY TEACHING HOSPITAL (ABUTH), KADUNA: A TWO YEAR RETROSPECTIVE STUDY
» Abstract Epilepsy is one of the most common neurological disorders worldwide with prevalence varying from place to place. In Nigeria, the prevalence i...Continue Reading »Item Type & Format: Project Material - Ms Word | 153 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
8. AWARENESS, ATTITUDE AND PRACTICE OF HEALTH CARE PROFESSIONALS TO ADVERSE DRUG REACTION REPORTING IN NNEWI NORTH L.G.A, ANAMBRA STATE.
» ABSTRACT This descriptive cross sectional survey was conducted on healthcare professionals working at different healthcare facilities in Nnewi North L...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
9. ANTIMICROBIAL EVALUATIONS OF THE ISOLATED COMPOUND OBTAINED FROM THE ETHYL ACETATE FRACTION OF Tridax procumbens Linn.
» ABSTRACT Tridax procumens Linn is a tropically distributed medicinal plant of the family Aseteracceae. The plant bears daisy like yellow centered whit...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT
-
10. COMPARATIVE PHYTOCHEMICAL ANALYSES OF METHANOLIC AND AQUEOUS LEAF EXTRACTS OF MEDICINAL PLANTS USED IN PLANT DISEASE CONTROL
» ABSTRACT: The aim of this research is to comparatively study the phytochemical and antimicrobial properties of Bryophyllum pinnatum and Citrus auranti...Continue Reading »Item Type & Format: Project Material - Ms Word | 61 pages |
Instant Download | Chapter 1-5 | PHARMACOLOGY DEPARTMENT