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Abstract
The concurrent use of herbal drugs and orthodox medicines for the treatment of various health
conditions is a common practice amongst patients; a practice that could result in drug-herb
interaction. This study evaluates the effects of Hibiscus sabdariffawater extract on thein vitro
and in vivo availability, as well as pharmacokinetics of metforminand lisinopril in healthy
human volunteers.For the determination of metformin and lisinopril in vitroin simulated
physiological pHs(0.1 M HCl, phosphate buffers pH of 6.8 and 7.4), three simples UV
spectrophotometric methodswere developed and validated according to ICH guidelines. The
in vitroavailability of metformin and lisinopril alone and in presence of Hibiscus sabdariffa
calyxes water extracts (1 g/L) in each of the three media(1 L and 900 mL) were
determinedusing dissolution apparatus (BP, 2013) set at 100and 50 rpm at 37 °C. Samples (5
mL) withdrawn from the media at 5, 10, 15, 30, 45, and 60 min were analysed for the
metformin and lisinopril content released using the appropriate developed method. For the
quantification of metformin and lisinopril in the in vivostudy, a RP-HPLC method was
developed and validated for each drug using caffeine as internal standard IS.The optimized
conditions comprise of a Chemsl ODS®C18 column (200 x 4.6 mm), binary mobile phase
(Methanol: Water 80:20)containing 0.1 % orthophosphoric acid as additive, isocratic elution
mode, 232 and 218 nm detection wavelengths flow rate of 1.0 mL/min and 10 µL injection
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SIMILAR PHARMACOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
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1. COMPARATIVE PHYTOCHEMICAL ANALYSES OF METHANOLIC AND AQUEOUS LEAF EXTRACTS OF MEDICINAL PLANTS USED IN PLANT DISEASE CONTROL
» ABSTRACT: The aim of this research is to comparatively study the phytochemical and antimicrobial properties of Bryophyllum pinnatum and Citrus auranti...Continue Reading »Item Type & Format: Project Material - Ms Word | 61 pages |
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2. ANTIOXIEANT ACTIVITY OF SEED EXTRACT AND FRACTIONS OF Monodora tsnuifolia (Annonaceae)
» ABSTRACT The antioxidant activity of the seed extract and fractions of Monodora tenuifolia (Fam. Annonaceae) was evaluated. The Monodora tenuifolia se...Continue Reading »Item Type & Format: Project Material - Ms Word | 101 pages |
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3. AVAILABILTY AND STORAGE OF VACINES IN COMMUNITY PHARMACIES
» CHAPTER ONE INTRODUCTION 1.0 Background of the Study Immunization is the process by which an individual’s immune system becomes fortified agains...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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4. SELF-MEDICATION AMONG UNDERGRADUATE PHARMACY STUDENTS OF UNIVERSITY OF UYO
» Abstract: Pharmacy students are expected to be more knowledgeable regarding rational use of medications as compared to the general public. A cross sec...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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5. BACTERIOLOGICAL ANALYSIS OF WATER IN HALLS OF RESIDENCE IN UNIVERSITY OF BENIN
» CHAPTER ONE 1.0 INTRODUCTION Water is indispensable and intricately connected to life, without which there is no life. This is the reason for which wa...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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6. ENUMERATON AND IDENTIFICATION OF BACTERIA ON USED HANDKERCHIEFS IN MALES
» ABSTRACT The enumeration, identification and characterization of bacteria on used handkerchiefs in males was carried out. A total of forty (40) handke...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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7. INVESTIGATION OF THE BACTERIA ASSOCIATED WITH URINARY TRACT INFECT IN PREGNANT WOMEN
» ABSTRACT The aim of this study was to determine the The Bacteria Associated With Urinary Tract Infect In Pregnant Women In University Of Uyo Teaching ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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8. KNOWLEDGE AND PRACTICE OF INFECTION CONTROL AMONG MIDWIVES IN LABOUR WARDS OF MAIDUGURI
» CHAPTER 1 INTRODUCTION 1.1 BACKGROUND Infection related diseases are still the main cause of death in Nigeria, according to the 2013 health profile ac...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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9. FEATURES, MANAGEMENT AND COST OF ILLNESS OF EPILEPSY IN AHMADU BELLO UNIVERSITY TEACHING HOSPITAL (ABUTH), KADUNA: A TWO YEAR RETROSPECTIVE STUDY
» Abstract Epilepsy is one of the most common neurological disorders worldwide with prevalence varying from place to place. In Nigeria, the prevalence i...Continue Reading »Item Type & Format: Project Material - Ms Word | 153 pages |
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10. THE WHOLISTIC NATURE OF AFRICAN TRADITIONAL MEDICINE: A CALL FOR SYNERGY WITH ORTHODOX MEDICINE
» CHAPTER ONE INTRODUCTION 1.1 Background of Study African traditional medicine is a medicine that is embedded in the religion of the people. In traditi...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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