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TABLE OF CONTENTS
Title Page - - - - - - - - - - i
Declaration - - - - - - - - - - ii
Certification - - - - - - - - - - iii
Dedication - - - - - - - - - - iv
Acknowledgements - - - - - - - - - v
Table of contents - - - - - - - - - vi
Abstract - - - - - - - - - - xi
CHAPTER ONE: INTRODUCTION
1.1 Background of Study - - - - - - - 1
1.2 Objective of Study- - - - - - - - - 4
1.3 Justification/Rationale for the Study- - - - - - 4
1.5 Significance of the Study- - - - - - - 6
CHAPTER TWO: LITERATURE REVIEW
2.1 Cannabis Sativa Plant Description- - - - - - 6
2.1.1 Seedling:- - - - - - - - - - 7
2.1.2 Stem: - - - - - - - - - - 7
2.1.3 Leaves:- - - - - - - - - - 7
2.1.4 Buds or flowers on the cannabis plant:- - - - - 7
2.1.5 Smell of the cannabis plant, especially the leaves and flowers- - 8
2.1.6 Discovery and cultivation- - - - - - - 8
2.2 Scientific Classification of Cannabis- - - - - - 9
2.2.1 Species of Marijuana-- - - - - - - - 10
2.2.1.1 Cannabis sativa- - - - - - - - - 10
2.2.1.2 Cannabis Indica- - - - - - - - 11
2.2.1.3 Cannabis Ruderalis- - - - - - - - 12
2.3 Economic Importance of Marijuana- - - - - - 15
2.4 Constituents of Cannabis- - - - - - - - 17
2.4.1 Phytocannabinoids -- - - - - - - - 17
2.4.2 Classification- - - - - - - - - 18
2.4.3 Noncannabinoid-Type Constituents- - - - - - 20
2.4.4 Hydrocarbons- - - - - - - - - 23
2.4.5 Nitrogen-Containing Compounds - - - - 23
2.4.6 Carbohydrates- - - - - - - - - 24
2.4.7 Flavonoids- - - - - - - - - - 24
2.4.8 Fatty Acids- - - - - - - - - - 25
2.4.9 Noncannabinoid Phenols- - - - - - - 25
2.4.10 Other- - - - - - - - - - 26
2.4.11 Cannabinoid Receptor System- - - - - - 26
2.4.12 Cannabinoid 1 and 2 Receptors- - - - - - 27
2.5 Sex Hormones and Its Synthesis- - - - - - 28
2.6 The Protein Hormones- - - - - - - - 28
2.6.1 The Gonadotropins- - - - - - - - 28
2.6.2 Luteinizing Hormone (LH)- - - - - - - 29
2.6.3 Human Chorionic Gonadotropin (hCG)- - - - - 30
2.6.4 Prolactin (Prl)- - - - - - - - - 31
2.7 The Steroid Hormones- - - - - - - - 32
2.7.1 Oestrogens- - - - - - - - - - 32
2.7.2 Oestradiol (E2)- - - - - - - - - 32
2.7.3 Oestrone (E1)- - - - - - - - - 33
2.7.4 Oestriol (E3)- - - - - - - - - 33
2.7.5 Progesterone (P4)- - - - - - - - - 34
2.7.6 Testosterone (T)- - - - - - - - - 35
2.8 Cannabis Effects- - - - - - - - - 35
2.8.1 Endocrine effects - - - - - - - - 35
2.8.2 Hypothalamic Pituitary-Gonadal Axis - - - - - 35
2.9 Hpg Axis Effects In Males - - - - - - 37
2.9.1 Effects on Reproductive Hormones in Males - - - - 37
2.10 Effects on Prolactin - - - - - - - 39
2.10.1 Effects on other Body Systems - - - - - 40
2.10.2 Vitamin C - - - - - - - - - 41
2.10.3 Biosynthesis and molecular structure of vitamin C - - 43
2.10.4 Redox metabolism and antioxidant properties of vitamin C- - 44
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