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Retention in HIV care or the continuous and uninterrupted receipt of comprehensive HIV care and treatment services is a health behaviour essential in reducing AIDS related morbidity/mortality, prolonging survival of persons living with HIV/AIDS (PLHIV) as well as achieving epidemic control by minimizing viral transmission and the incidence of new HIV infections. It is a health promoting behaviour that is of particular importance in countries with the highest HIV disease burden including Nigeria, with over 10% of the global HIV disease burden. Although studies have confirmed that retention rates are sub-optimal both in developed and developing countries, there is limited information on how retention rates vary with time in Nigeria. This study was therefore conducted to determine the percentage of HIV-infected adults that were continuously retained in HIV care 36 months after starting antiretroviral treatment (ART) as well as identify barriers and facilitators of retention.
This study employed a mixed-method research design and was conducted at State Specialist Hospital, Akure in Ondo state, Nigeria. A total of 420 HIV-infected persons who started antiretroviral treatment between January and December 2013 were purposively selected and retrospectively followed up for a total of 36 months in order to determine retention rates (operationalized using the 4-month hospital visit constancy measure); by 12, 24 and 36 months post-treatment initiation. Additionally, 12 in-depth interviews were conducted with HIV-infected persons receiving treatment at the facility in order to elicit barriers and facilitators of retention in HIV care. The socio-ecological framework of health promotion guided the coding of qualitative research data while grounded and density analysis was used in identifying the most significant barriers and facilitators of retention in HIV care.
In this study, retention rates were observed to decline significantly among both males and females. Retention rates at 12, 24 and 36 months were 57.95%, 50.00% and 40.22% for males and 77.24%, 63.31% and 49.74% for females, respectively. Stigma, poor health literacy and clinic distance/lack of transportation fare were the most important barriers to retention while good health literacy and a positive healthcare worker – client relationship were the most significant facilitators of retention identified by study participants.
In conclusion, the study highlights the need for novel strategies to promote retention especially among men. These strategies include prioritization and allocation of resources by HIV program planners to facilitate implementation of health promotion interventions; the development of a national HIV/AIDS patient education curriculum to promote health literacy; the conduct of regular mass media campaigns to address HIV-related stigma in the community. There is also a need for large-scale studies that better characterizing the barriers of retention particularly the dimensions of HIV-related stigma in Nigeria.
Keywords: Human Immunodeficiency Virus (HIV); Retention in HIV care; Retained in HIV care; Barriers to retention in HIV care; Facilitators of retention in HIV care
1.1 Background to the Study
The Human Immunodeficiency Virus (HIV) belongs to the family of ‘retroviruses’ and possesses the ability to transform its genetic material from viral ribonucleic acid (RNA) into deoxyribonucleic acid (DNA) and then subsequently integrate the latter into the genome of an infected human cell (Maartens, Celum, & Lewin, 2014). These processes, referred to as reverse transcription and integration, combined with a high mutagenicity currently constitute significant barriers to the creation of a cure for the virus. Antiretroviral medications (ARVs) interfere with replication of the virus in specific cells of the immune system (expressing CD4 receptors on their cell surfaces) through varying mechanisms resulting in virologic suppression; characterized by an undetectable level of the virus in the human circulatory system and represents the primary goal of antiretroviral therapy. Indirect benefits that follow virologic suppression include recovery of the immune system; a reduction in AIDS related morbidity; an improved life expectancy and a significant reduction in the risk of transmission of the virus (Cohen, et al., 2016).
The receipt of antiretroviral medications is therefore a lifelong process and for HIV-infected persons to benefit maximally from ARV therapy, they must be optimally retained in care. Retention in HIV care describes the continuous and uninterrupted receipt of comprehensive HIV care and treatment services following HIV diagnosis and successful linkage to care and is an important health behaviour necessary to ensure continuous receipt of antiretroviral medications; evaluation of drug toxicities; early identification of treatment failure (Geng, et al., 2010); and ongoing receipt of comprehensive health education that in turn promotes medication adherence.
From an individual standpoint, retention in care is important as it is a strong predictor of virologic suppression and prolonged survival for persons living with HIV/AIDS (PLHIV) (Colasanti, et al., 2016). Countries of sub-Saharan Africa, particularly South Africa and Nigeria are disproportionately affected by HIV (UNAIDS, 2016); and in these countries, retention in HIV care is a public health priority as intimated by a study that observed that HIV-infected persons who are poorly retained were the most significant source of new HIV infections in the United States (Skarbinski, et al., 2015). From a health promotion standpoint however, retention in care provides an indirect reflection of the readiness of HIV-infected persons to increase control over, and improve their health. Several studies however, suggest that retention in HIV care is sub-optimal both in developed and developing countries (McCutchan, 2009).
1.2 Statement of the Problem
In a recent study conducted in the United States, retention rates were observed to decline from 84% to 60% and 49% at 12, 24 and 36 months post-initiation of antiretroviral therapy, respectively (Colasanti, et al., 2016). In sub-Saharan Africa, the earliest systematic review of retention in HIV care observed that among 74,000 HIV-infected persons across 13 countries, the proportion of persons who were alive and receiving ARVs 24 months post-initiation of treatment was approximately 60% (Rosen, Fox, & Gill, 2007). In an updated meta-analysis published in 2010, the authors observed that 24- and 36-month retention rates for 226,307 persons from 39 patient-cohorts was 70% and 64.6% respectively (Fox & Rosen, 2010). In Nigeria, most studies conducted to assess retention rates have been cross-sectional in nature. In one study, 75% of 3,878 HIV-infected adults who started ARVs between 2005 and 2009 across 37 treatment facilities in Nigeria were retained in care by 2010 (Ugoji, et al., 2015). In another cross-sectional study conducted in Ekiti state, only 63% of HIV-infected persons who started ARVs between 2005 and 2011 at a large tertiary hospital were retained in care by 2012 (Babatunde, et al., 2015). Cross-sectional analyses typically over-estimate retention rates and do not provide information on changes in retention rates over time.
Several studies have also been conducted to determine factors that predict retention in HIV care including demographic factors such as younger age, male gender, lower level of education and socio-economic status; availability of social support; adherence counselling; disclosure of HIV status; presence of severe mental illness; clinic related factors; HIV disease progression and HIV sero-discordance (Bulsara, Wainberg, & Newton-John, 2016). In the study of factors influencing this important health behaviour (retention in HIV care); most studies failed to conceptualize their research using a theory of health behaviour.
It is therefore on the premise of the large disease burden in sub-Saharan Africa particularly Nigeria; coupled with limitations of existing studies that this study sort to determine how retention rates varied over time while also determining barriers and facilitators of retention in HIV care in Nigeria.
1.3 Objective of the Study
The specific objectives are to:
1. determine the percentage of HIV-infected adults that are continuously retained in care after 36 months of initiating antiretroviral treatment;
2. identify barriers to retention in care among HIV infected adults on antiretroviral treatment and
3. identify facilitators of retention in care among HIV infected adults on antiretroviral treatment
1.4 Research Questions
Research questions that guided this study were the following:
1. What percentage of HIV-infected adults is continuously retained in care after 36 months of initiating antiretroviral treatment?
2. What are the barriers to retention in care among HIV infected adults on antiretroviral treatment?
3. What are the facilitators of retention in care among HIV infected adults on antiretroviral treatment?
1.5 Justification for Study
Sub-optimal retention in HIV care has deleterious effects both from the individual and public health perspective. Poor retention in HIV care has been linked with poor medication adherence, development of antiretroviral drug resistance and an increased risk of death from Acquired Immunodeficiency Syndrome (AIDS) – the hallmark of HIV infection characterized by severe, debilitating and life-threatening opportunistic infections. From a public health standpoint, interventions to promote retention in HIV care are needed in order to reduce the transmission and incidence of new HIV infections within communities; reduce the burden placed on an already weak healthcare system as well as reduce healthcare costs associated with HIV treatment, prevention and control. HIV-infected persons who are poorly retained in care typically have higher viral loads and are significantly more likely to transmit the virus to others. In high burden settings like Nigeria, there is therefore an important need to employ health promotion strategies that promote health literacy through health education both for infected individuals and the communities they reside in.
This study is unique as it is one of a few studies conducted in Nigeria to estimate retention rates longitudinally, over a 36-month period thus, providing a more accurate estimate of retention among HIV-infected persons on antiretroviral treatment. Furthermore, this study conceptualized using the socio-ecological model also elicited barriers and facilitators of optimal retention in HIV care in Nigeria. The results of this study contribute new knowledge that will act as a roadmap guiding the design and implementation of effective interventions to improve retention in HIV care in Nigeria.
1.6 Operational Definition of Terms
Antiretroviral Treatment (ART): is a combination of at least 3 potent antiretroviral medications used in the lifelong management of HIV
HIV Continuum of Care: is a framework that describes the various steps that persons living with HIV must proceed through in order to achieve virologic suppression namely diagnosis, linkage to HIV care and ART eligibility assessment, initiation and maintenance of ART and the achievement of viral suppression.
Virologic Suppression: is the suppression of HIV viral load to levels below 1,000 viral copies per millilitre (ml) of blood due to inhibition of replication by antiretroviral medications.
Retention in HIV Care: the continuous and uninterrupted receipt of comprehensive HIV care and treatment services following successful linkage to care; operationalized in this study, as ‘4-month hospital visit constancy’ or the ‘number of 4-month intervals with at least 1 clinic visit’.
HIV Treatment Naive: refers to HIV-positive persons who have never been initiated on or taken any antiretroviral medications for HIV.
HIV Treatment Experienced: refers to HIV-positive persons who have been initiated on antiretroviral medications at any time since they were diagnosed with HIV.
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