- The Complete Research Material is averagely 162 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦7,000
Get the complete project »
ABSTRACT
The antioxidant potential of many flavonoid containing plants is increasingly being
exploited in therapy. Hibiscus sabdariffa (HS) is one of the most widely used nutraceuticals
used traditionally to combat various illnesses due to its high flavonoid contents. The present
study was aimed at evaluating the ameliorative effect of co-administration of HS and
vitamin E on sub-chronic carbamazepine (CBZ)-induced alterations in semen
characteristics. Thirty young male Wistar rats were divided at random into five groups
containing 6 rats per groups. Group I and II were administered normal saline and
carbamazepine (20 mg /kg), respectively, while group III was treated with CBZ and aqueous
extract of Hibiscus Sabdariffa (200 mg/kg); group IV was treated with CBZ and vitamin E
(VE) 30 minutes after treatment with CBZ. The regimens were administered orally by
gavage once daily for a period of 8 weeks. At the end of the treatment, four animals from
each group were randomly selected and sacrificed by jugular fenestration. The result
obtained showed that CBZ caused a pronounced reduction in sperm concentration, motility,
testicular histological damage, sperm morphological abnormalities, and increased the
testicular MDA concentration. In control group, sperm count was 61.50 ± 1.44 x106/ml, and
49.75 ± 3.19 x106/ml, 71.25 ± 7.08 x106/ml, 63.00 ± 2.67 x106/ml and 89.00 ± 9.85 x106/ml
for CBZ, CBZ + HS, CBZ + VE and CBZ + HS + VE groups respectively. Sperm
progressive motility was 61.25 ± 3.14%, 42.50 ± 4.78%, 66.25 ± 6.88%, 67.50 ± 6.29% and
82.50 ± 4.78% for the control, CBZ, CBZ + HS, CBZ + VE and CBZ + HS + VE groups
respectively, sperm non-progressive motility was 26.25 ± 2.39%, 30.00 ± 4.56%, 20.00 ±
3.53%, 17.50 ± 2.50%, and 7.50 ± 1.44% for the control, CBZ, CBZ + HS, CBZ + VE and
CBZ + HS + VE groups respectively, while, non-motile sperm cells was 22.50 ± 4.78%,
27.50 ± 1.44%, 13.75 ± 3.75%, 15.00 ± 5.00%, and 10.00 ± 3.53% for the control, CBZ,
7
CBZ + HS, CBZ + VE and CBZ + HS + VE groups respectively. Serum testosterone
concentration in control group was 6.15 ± 0.22 µg/ml, and 5.05 ± 0.06 µg/ml, 4.25 ± 0.34
µg/ml, 4.70 ± 0.16 µg/ml, and 5.97 ± 0.31 µg/ml for CBZ, CBZ + HS, CBZ + VE and CBZ
+ HS + VE groups respectively. The testicular MDA concentration was 0.05 ± 0.01
nmoL/mg, 0.17 ± 0.012 nmoL/mg, 0.04 ± 0.02 nmoL/mg, 0.06 ± 0.
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
-
SIMILAR PHYSIOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
-
1. EFFECT OF VITAMIN E AND RESVERATROL ON OXIDATIVE STRESS AND HAEMATOLOGICAL PARAMETERS OF CARBAMAZEPINE-INDUCED OXIDATIVE STRESS IN MALE WISTAR RATS
» ABSTRACT Carbamazepine (CBZ) is a drug used in the treatment of epilepsy and neuropathic pain. Carbamazepine induces oxidative stress and haematologic...Continue Reading »Item Type & Format: Project Material - Ms Word | 89 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
2. MODULATORY ROLE OF RESVERATROL-INDUCED DIETARY RESTRICTION AND ENVIRONMENTAL ENRICHMENT ON NEUROBEHAVIOURAL OUTCOME IN YOUNG HEALTHY MICE
» ABSTRACT Dietary Restriction (DR) otherwise known as Caloric Restriction (CR) has been generally defined as consumption of nutritious diet that is 30%...Continue Reading »Item Type & Format: Project Material - Ms Word | 144 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
3. EFFECT OF WATER RESTRICTION AND ASCORBIC ACID SUPPLIMENTATION ON RECTAL TEMPERATURE, BODY WEIGHT AND HEMATOLOGICAL INDICES IN JAPANESE QUAILS IN SOKOT...
» TABLE OF CONTENTS TitleDedicationCertificationAcknowledgementsTable of contentsList of TablesList of FiguresList of PlatesAbstract iiiiiiivvixxixiixii...Continue Reading »Item Type & Format: Project Material - Ms Word | 79 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
4. STUDY OF THE EFFECTS OF AZADIRACTA INDICA SEED EXTRACT ON BLOOD GLUCOSE LEVELS OF NORMOGLYCEMIC AND STREPTOZOCIN-INDUCED DIABETIC WISTAR RATS.
» ABSTRACT This study investigated the effects of Azadiracta Indica seed extract on blood glucose levels of streptozocin induced diabetic and normoglyce...Continue Reading »Item Type & Format: Project Material - Ms Word | 195 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
5. HYPOGLYCEMIC AND HEPATO-PROTECTIVE EFFECTS OF HYDRO-ETHANOL SILK OF Zea-Mays EXTRACT ON ALLOXAN-INDUCED DIABETIC WISTAR RATS
» ABSTRACT Globally, as of 2010, an estimated 285 million people had diabetes, with type 2 making up about 90% of the cases The management of diabetes w...Continue Reading »Item Type & Format: Project Material - Ms Word | 105 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
6. IMPACT OF PERSONALITY TRAITS ON INTERPERSONAL DEPENDENCE AMONG UNDERGRADUATES IN IMO STATE
» ABSTRACT This study is to examine the impact of personality traits on interpersonal dependence among undergraduates in Imo State with a particular ref...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
7. INFLUENCE OF SHIFT WORK AND MARITAL STATUS ON OCCUPATIONAL STRESS AMONG NURSES IN NIGERIA
» Abstract Work Related Stress (WRS) is the harmful physical and emotional responses that occur when the requirements of job do not match the capabiliti...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
8. EVALUATION OF PROLONGED ADMINISTRATION OF ARTEMETHER-LUMEFANTRINE ON SPERM INDICES AND TESTICULAR BIOMARKERS OF OXIDATIVE STRESS IN MALE WISTAR RATS: ...
» ABSTRACT There is frequent use of artemisinin based combination therapies (ACTs) due to recurrence of malaria infection in Nigeria. The ACTs generate ...Continue Reading »Item Type & Format: Project Material - Ms Word | 104 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
9. EVALUATION OF ANTICONVULSANT ACTIVITY OF DATE (PHOENIX DACTYLIFERA) IN MICE AND CHICKS
» ABSTRACT Phoenix dactylifera contains some phytochemical constituents which have been reported to be associated with different pharmacological activit...Continue Reading »Item Type & Format: Project Material - Ms Word | 75 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT
-
10. EFFECT OF AMBIENT TEMPERATURE ON METHYLENEDIOXYMETHAMPHETAMINE (MDMA)-INDUCED CHANGES IN BODY TEMPERATURE, NEUROBEHAVIOUR AND NEUROTOXICITY IN RODENTS
» ABSTRACT Studies on the effect of ambient temperature on methylenedioxymethamphetamine (MDMA) induced changes in body temperature, neurobehaviour and ...Continue Reading »Item Type & Format: Project Material - Ms Word | 143 pages | Instant Download | Chapter 1-5 | PHYSIOLOGY DEPARTMENT