ABSTRACT

Dermatophytosis is a common fungal infection of the skin in humans and animals. This

study evaluates anti-fungal activity of Chlorophytum laxum (R Br) extract on fungi

isolates associated with tinea capitis. The whole plant was extracted and subjected to

phytochemical screening and the fractions were analyzed using gas- chromatography and

mass spectrometry. The bioassay was done using food poisoning technique method.

Trichophyton spp and Microsporum spp were the fungal isolated and identified. The

crude extract of Chlorophytum laxum at 50mg/ml showed the highest zone of inhibition

on the isolates: Microsporum spp (30.00 ± 6.1), trichophyton spp (37.3 ± 1.2), and

trichophyton spp (60.3 ± 0.9) respectively significantly different (P < 0.05). Gas-

chromatography/Mass-Spectrometry      analysis      identified     Dimethyl     sulfone,     4-

Methylvaleric acid, 1-Propanol and 5H- Tetrazol-5-amine as bioactive compounds that

have antifungal properties in the fractions. The data obtained were subjected to analysis

of variance at p<0.05 using SPSS version 20 and means were separated using least

significant difference (LSD) This study therefore showed that, the effectiveness of

C.laxum inhibit Microsporum spp and Trichophyton spp which were found to causes

tinea capitis infection from scalp scrapings among primary school pupils in Zaria and

suggests the scientific reason for the traditional use of the plant in treatment of fungal

infection.

 CHAPTER ONE

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