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Abstract
Onchocerciasis, a neglected tropical disease (NTD), also known as river blindness, the
world‟s second leading cause of preventable blindness is caused by helminths worm
Onchocerca volvulus. This parasite lives and multiplies extracellularly in the blood and tissue
fluids of their human hosts and is transmitted by the bite of infected blackfly(Simulium
damnosum)of the family Simuliidae. O. volvulus GST1 (OvGST1) modulates immune
responses through the synthesis of parasite-derived prostanoids and xenobiotic detoxification,
thus preventing effector responses. The OvGST1differential expression profile in specific
stages of O. volvulus quantified using qPCR relative gene expression technique. The results
reveal that OvGST1 is well expressed in the L3 insect developmental stage and microfilaria
stage in the human host but poorly expressed in the adult worms of O. volvulus in the human
host. Differential expression from skin microfilaria revealed 2.55-fold up-regulation relative
to the L3 insect stage of the parasite which in turn revealed a higher OvGST1differential
expression compared to adult worms. Reduced glutathione was higher in the human tissues
compared to the Simulium proboscis and did not positively correlate with OvGST1 expression
i
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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1. ASSESSMENT OF THE RELATIONSHIP BETWEEN FOETAL HAEMOGLOBIN LEVELS, MARKERS OF TISSUE DESTRUCTION AND DISEASE SEVERITY IN INDIVIDUALS WITH SICKLE CELL ...
» ABSTRACT Sickle cell Anaemia is a genetic disorder that leads to the production of Sickle haemoglobin, whichresults in abnormal functions of the red b...Continue Reading »Item Type & Format: Project Material - Ms Word | 72 pages |
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2. BIOCHEMISTRY OF GOUT
» CHAPTER ONE INTRODUCTION 1.1 Introduction Gout was described by Hippocrates as “the disease of kings” due to its association with rich diet. (Fala...Continue Reading »Item Type & Format: Project Material - Ms Word | 31 pages |
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3. A PROJECT RESEARCH INTO SERUM CALCIUM LEVEL IN GERIATRIC MEN, COMPERATIVE STUDIES
» ABSTRACT Calcium is the most important mineral in the body. The body needs calcium for normal functioning of nerves and muscles including the most imp...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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4. EVALUATION OF THE ANTIDIABETIC EFFECTS OF WATER AND METHANOLIC EXTRACTS OF AVOCADO (PERSEA AMERICANA) SEED ON ALLOXAN INDUCED DIABETIC RATS
» ABSTRACT The high prevalence, complications and cost of conventional drugs in the management diabetes necessitated the search for alternative treatmen...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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5. AMELIORATING ROLE OF N.P.K. FERTILIZER ON THE TOXIC EFFECTS OF Ni ON (SORGHUM) ROOT ANTIOXIDANT ENZYMES
» ABSTRACT This study investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutothione peroxidase (GP) and the level of malondiald...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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6. ANTISICKLING EFFECT AND ACTIVITY GUIDED FRACTIONATION OF DICHROSTACHYS CINEREA (Wight & Arn) ROOT AND STERCULIA SETIGERA (Del) LEAF METHANOLIC EXTRA...
» ABSTRACT The in vitro antisickling effects of the crude methanolic extract, ethyl acetate, n hexane, butanol, and aqueous fractions of methanolic extr...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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7. EFFECT OF ETHANOL LEAF EXTRACT OF Vernonia Amygdalina ON THEOBROMINE INDUCED RENAL TOXICITY IN MALE WISTAR RATS
» CHAPTER ONE 1.0 Introduction 1.1 Background of the Study In most plants synthesizing methylxanthines, caffeine becomes the principal constituent. In s...Continue Reading »Item Type & Format: Project Material - Ms Word | 42 pages |
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8. EVALUATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF LEAF AND ROOT OF ZIZIPHUS LOTUS L ON MULTIDRUG RESISTANT BACTERIA
» ABSTRACT Treatment of infectious disease is a major public health challenge due to the continual increase in drug resistance by microorganisms. Plants...Continue Reading »Item Type & Format: Project Material - Ms Word | 102 pages |
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9. EFFECTS OF ETHANOL, METHANOL AND N-HEXANE LEAF AND FRUIT EXTRACTS OF Kigelia africana ON SOME OXIDATIVE AND BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED ...
» ABSTRACT Globally, the estimated incidence of diabetes and projection for the year 2030 as given by the International Diabetes Federation (IDF) is 350...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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10. BACTERIOLOGICAL EXAMINATION OF PALM WINE SOLD AT UDI LOCAL GOVERNMENT AREA
» ABSTRACT This work shows how to identify the various microorganism in palm wine and how to isolate the pathogenic organism in palm wine vie Nkwuenu an...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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