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Abstract
Onchocerciasis, a neglected tropical disease (NTD), also known as river blindness, the
world‟s second leading cause of preventable blindness is caused by helminths worm
Onchocerca volvulus. This parasite lives and multiplies extracellularly in the blood and tissue
fluids of their human hosts and is transmitted by the bite of infected blackfly(Simulium
damnosum)of the family Simuliidae. O. volvulus GST1 (OvGST1) modulates immune
responses through the synthesis of parasite-derived prostanoids and xenobiotic detoxification,
thus preventing effector responses. The OvGST1differential expression profile in specific
stages of O. volvulus quantified using qPCR relative gene expression technique. The results
reveal that OvGST1 is well expressed in the L3 insect developmental stage and microfilaria
stage in the human host but poorly expressed in the adult worms of O. volvulus in the human
host. Differential expression from skin microfilaria revealed 2.55-fold up-regulation relative
to the L3 insect stage of the parasite which in turn revealed a higher OvGST1differential
expression compared to adult worms. Reduced glutathione was higher in the human tissues
compared to the Simulium proboscis and did not positively correlate with OvGST1 expression
i
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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1. PROXIMATE ANALYSIS OF SEED AND COAT OF VELVET BEAN (Mucuna pruriens) AND CAMWOOD (Baphia nitida)
» CHAPTER ONE 1.0 INTRODUCTION Seed and coat of Mucuna pruriens, known as velvet beans or cowitch has scientific classification as shown below; Kingdom ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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2. ANTIDIARRHOEAL AND ANTIBACTERIAL ACTIVITIES OF METHANOLIC EXTRACTS AND FRACTIONS OF THE PULP AND SEED OF ZIZIPHUS MAURITIANA (CHINEE APPLE
» ABSTRACT This study evaluated, the antidiarrhoeal and antibacterial activity of the methanolic extracts of seed and pulp of Ziziphus mauritania. The c...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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3. ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS.
» ABSTRACT Anti hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root ba...Continue Reading »Item Type & Format: Project Material - Ms Word | 145 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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4. UREA AND CREATININE CONCENTRATIONS OF PLASMODIUM BERGHEI INFECTED MICE TREATED WITH COARTEM, HIPPROCRATEA AFRICANA ROOT BARK EXTRACT, CIPROFLOXACIN AN...
» ABSTRACT The concomitant effect of Hippocratea africana root bark extract, Jatropha tanjorensis Ciprofloxacin and Coartem on markers (Urea and Creatin...Continue Reading »Item Type & Format: Project Material - Ms Word | 57 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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5. ANALYSIS OF SOME MINERAL CONTENTS OF COCONUT WATER
» CHAPTER ONE INTPDUCTION Background of the Study The coconut (Cocos nucifera L.) is a tropical plant which belongs to the order Arecales and family Are...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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6. MODULATORY EFFECT OF ETHANOLIC LEAF EXTRACT OF SPHENOCENTRUM JOLLYANUM PIERRE (SPJ) ON LIVER FUNCTION AND HAEMATOLOGICAL INDICES OF CADMIUM CHLORIDE-I...
» ABSTRACT The effect of ethanolic leaf extract of Sphenocentrum jollyanum pierre (SPJ) on liver function and hematological indices of cadmium chloride ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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7. QUALITATIVE PHYTOCHEMICAL ANALYSIS OF S. aculeastrum SEED
» ABSTRACT Solanum aculeastrum is an important medicinal plant commonly known as soda apple, soda apple nightshade, goat apple, poison apple or more amb...Continue Reading »Item Type & Format: Project Material - Ms Word | 24 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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8. A STUDY OF THE PHARMACOLOGICAL EFFECTS OF METHANOL EXTRACT OF RIPE AND UNRIPE PLANTAIN
» INTRODUCTION 1.1 Background to Study Natural products, such as plants extract, either as pure compounds or as standardized extracts, provi...Continue Reading »Item Type & Format: Project Material - Ms Word | 70 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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9. COMBINED EFFECT OF ETHANOLIC EXTRACT OF GONGRONEMA LATIFOLIUM AND ALLIUM SATIVUM ON LIPID PROLIFE PARAMETERS ON STREPTOZOTOCIN INDUCED DIABETIC WISTAR...
» TABLE OF CONTENT Title page i Cover page ii Certification iii Dedication iv Acknowledgment v Abstract vi Table of content vii CHAPTER ONE: INTRODUCTIO...Continue Reading »Item Type & Format: Project Material - Ms Word | 60 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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10. ALTERATION OF SIALIC ACID LEVELS DURING PLASMODIUM FALCIPARUM INFECTION IN HUMANS
» Abstract Malaria is still a major disease that causes millions of deaths, mostly among children under five years old and pregnant women, in tropical c...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT