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Abstract
Onchocerciasis, a neglected tropical disease (NTD), also known as river blindness, the
world‟s second leading cause of preventable blindness is caused by helminths worm
Onchocerca volvulus. This parasite lives and multiplies extracellularly in the blood and tissue
fluids of their human hosts and is transmitted by the bite of infected blackfly(Simulium
damnosum)of the family Simuliidae. O. volvulus GST1 (OvGST1) modulates immune
responses through the synthesis of parasite-derived prostanoids and xenobiotic detoxification,
thus preventing effector responses. The OvGST1differential expression profile in specific
stages of O. volvulus quantified using qPCR relative gene expression technique. The results
reveal that OvGST1 is well expressed in the L3 insect developmental stage and microfilaria
stage in the human host but poorly expressed in the adult worms of O. volvulus in the human
host. Differential expression from skin microfilaria revealed 2.55-fold up-regulation relative
to the L3 insect stage of the parasite which in turn revealed a higher OvGST1differential
expression compared to adult worms. Reduced glutathione was higher in the human tissues
compared to the Simulium proboscis and did not positively correlate with OvGST1 expression
i
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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1. AN ASSESSMENT OF TEACHERS’ KNOWLEDGE OF TEST CONSTRUCTION PROCEDURE IN CHEMISTRY OBJECTIVE TEST IN SENIOR SECONDARY SCHOOLS
» CHAPTER ONE INTRODUCTION Background of Study Testing has always been an integral part of the educational system since its inception. The concept (test...Continue Reading »Item Type & Format: Project Material - Ms Word | 90 pages |
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2. A COMPARATIVE STUDY OF THE EFFECTIVENESS OF DISCUSSION VERSUS DEMONSTRATION ON STUDENTS ACHIEVEMENT AND RETENTION IN CHEMISTRY
» CHAPTER ONE 1.0 INTRODUCTION 1.1 BACKGROUND OF STUDY Engagement in meaningful learning is a universal theme advanced in literature on student’s achi...Continue Reading »Item Type & Format: Project Material - Ms Word | 65 pages |
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3. EFFECTS OF PROCESSING METHODS ON THE PHYSICO-CHEMICAL PROPERTIES OF SWEET POTATO AND SORGHUM
» CHAPTER ONEINTRODUCTIONSweet potato (Ipomoea batatas) is an important food crop in the tropical and sub tropical countries and belongs to the family c...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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4. EFFECT OF ETHANOL LEAF EXTRACT OF Vernonia Amygdalina ON THEOBROMINE INDUCED RENAL TOXICITY IN MALE WISTAR RATS
» CHAPTER ONE 1.0 Introduction 1.1 Background of the Study In most plants synthesizing methylxanthines, caffeine becomes the principal constituent. In s...Continue Reading »Item Type & Format: Project Material - Ms Word | 42 pages |
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5. COMPARATIVE QUANTITATIVE PHYTOCHEMICAL ANALYSIS OF ETHANOL EXTRACT OF Gongronema latifolium AND Allium sativum
» TABLE OF CONTENTS Cover page Title page Certification i Dedication ii Acknowledgement iii Abstract iv Table of content V List of tables vi CHAPTER ONE...Continue Reading »Item Type & Format: Project Material - Ms Word | 44 pages |
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6. NUTRITIONAL AND ANTI-NUTRITIONAL COMPOSITION OF DETARIUM MICROCARPUM
» ABSTRACT The pulp of Detarium microcarpum fruit was obtained and was analyzed for the proximate, mineral and anti nutrient composition using standard ...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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7. ANTI-HYPERLIPIDEMIC POTENTIAL OF VITEX DONIANAETHANOLEXTRACTS ON POLOXAMER 407 INDUCED HYPERLIPIDEMIC AND NORMAL RATS.
» ABSTRACT Anti hyperlipidemic potential of extracts (aqueous, 70% methanol, 70% ethanol and 70%, acetone) of Vitexdoniana leaves, stem bark and root ba...Continue Reading »Item Type & Format: Project Material - Ms Word | 145 pages |
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8. PROXIMATE AND PHYSICOCHEMICAL ANALYSIS OF FISH FLOUR OBTAINED FROM THREE FISH SPECIES
» ABSTRACT Work on production proximate and physicochemical analyses of fish flour produced from Tilapia, cat and stock fishes was investigated. The fis...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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9. CONTROLLING GLOBAL OBESITY EPIDEMIC
» ABSTRACT Obesity is a condition of increased adipose tissue mass as a result of excessive accumulation of fat. This increase in body fat increases the...Continue Reading »Item Type & Format: Project Material - Ms Word | 41 pages |
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10. THE EVALUATION OF MICROORGANISMS ON GARRI AT OGBETE MARKET
» ABSTRACT The research focus on compensation policy as means of attracting and retaining employee, it present a conceptual and theoretical study of the...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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