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Abstract
Onchocerciasis, a neglected tropical disease (NTD), also known as river blindness, the
world‟s second leading cause of preventable blindness is caused by helminths worm
Onchocerca volvulus. This parasite lives and multiplies extracellularly in the blood and tissue
fluids of their human hosts and is transmitted by the bite of infected blackfly(Simulium
damnosum)of the family Simuliidae. O. volvulus GST1 (OvGST1) modulates immune
responses through the synthesis of parasite-derived prostanoids and xenobiotic detoxification,
thus preventing effector responses. The OvGST1differential expression profile in specific
stages of O. volvulus quantified using qPCR relative gene expression technique. The results
reveal that OvGST1 is well expressed in the L3 insect developmental stage and microfilaria
stage in the human host but poorly expressed in the adult worms of O. volvulus in the human
host. Differential expression from skin microfilaria revealed 2.55-fold up-regulation relative
to the L3 insect stage of the parasite which in turn revealed a higher OvGST1differential
expression compared to adult worms. Reduced glutathione was higher in the human tissues
compared to the Simulium proboscis and did not positively correlate with OvGST1 expression
i
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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1. STUDY ON THE DESTABILIZATION OF LYSOZYME AND THE CHAPERONE-LIKE ACTIVITY OF ALPHA CRYSTALLIN FROM SOKOTO RED GOAT EYE LENS
» ABSTRACT Destabilization of Lysozyme and chaperone like action of alpha crystallin isolated from goat’s eye lens was investigated at various tempera...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages |
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2. DETERMINATION OF ACTIVE SWEET COMPONENTS OF COMMON ARTIFICIAL SWEETENERS THAT ARE USED AS REPLACEMENT FOR SUGAR
» CHAPTER FIVE DISCUSSION AND CONCLUSION Discussion: Table 1 shows the taste with distilled waterused as control. In Table 2, there is a change in the t...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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3. BIODIESEL AS ALTERNATE SOURCE OF ENERGY
» INTRODUCTION 1.0 GENERAL INTRODUCTION Energy is a fundamental pillar of modern society as well as being an essential building block for socio economic...Continue Reading »Item Type & Format: Project Material - Ms Word | 41 pages |
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4. EFFECTS OF ETHANOLIC ROOT EXTRACT OF UGU OYIBO (Jatropha tanjorensis) ON HAEMATOLOGICAL INDICES OF FEMALE ALBINO WISTAR RAT
» ABSTRACT Jatropha tanjorensis is a natural medicinal herb which has been used over the years in the treatment of many health disorders. This study was...Continue Reading »Item Type & Format: Project Material - Ms Word | 76 pages |
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5. PHYTOCHEMICAL SCREENING OF ETHANOL LEAVES EXTRACT OF Jatropha tanjorensis AND ITS EFFECTS ON THE LIVER FUNCTION OF MALE ALBINO WISTAR RATS
» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND INFORMATION Plants have been used sinced the medieval times for medicinal purposes for the treatment of all ki...Continue Reading »Item Type & Format: Project Material - Ms Word | 71 pages |
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6. EFFECTS OF KOLAVIRON ON LYMPHOCYTES PROLIFERATION, EXPRESSION OF TOLL LIKE RECEPTOR-2 AND VASCULAR ENDOTHELIAL GROWTH FACTOR-C GENES IN Wuchereria ban...
» ABSTRACT The anti proliferative effect and down regulation of vascular endothelial growth factor C and toll like receptor 2 by kolaviron rich portion ...Continue Reading »Item Type & Format: Project Material - Ms Word | 72 pages |
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7. AN ASSESSMENT OF TEACHERS’ KNOWLEDGE OF TEST CONSTRUCTION PROCEDURE IN CHEMISTRY OBJECTIVE TEST IN SENIOR SECONDARY SCHOOLS
» CHAPTER ONE INTRODUCTION Background of Study Testing has always been an integral part of the educational system since its inception. The concept (test...Continue Reading »Item Type & Format: Project Material - Ms Word | 90 pages |
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8. EVALUATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT OF LEAF AND ROOT OF ZIZIPHUS LOTUS L ON MULTIDRUG RESISTANT BACTERIA
» ABSTRACT Treatment of infectious disease is a major public health challenge due to the continual increase in drug resistance by microorganisms. Plants...Continue Reading »Item Type & Format: Project Material - Ms Word | 102 pages |
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9. CARDIO PROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTER RAT
» ABSTRACT This study evaluates the effect of the cardio protective N hexane extract of Desmodium stem velutinum on wister albino rat. The rats used in ...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages |
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10. COMPARATIVE STUDY OF THE EFFECTS OF ETHANOL LEAVES AND STEM EXTRACTS OF Jatropha tanjorensis (Hospital Too Far) ON SOME LIVER FUNCTIONS OF MALE ALBINO...
» CHAPTER ONE INTRODUCTION 1.1 Background of Study Jatropha tanjorensis, commonly referred to as “hospital too far” or Ugu Oyibo in Igbo language be...Continue Reading »Item Type & Format: Project Material - Ms Word | 57 pages |
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