Get the complete project »
- The Complete Research Material is averagely 52 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦4,000
1.1 Background of the study
Antiseptics and disinfectants are used extensively in hospitals and other health care settings for a variety of topical and hard-surface applications. In particular, they are an essential part of infection control practices and aid in the prevention of nosocomial infections. Mounting concerns over the potential for microbial contamination and infection risks in the food and general consumer markets have also led to increased use of antiseptics and disinfectants by the general public. A wide variety of active chemical agents (or “biocides”) are found in these products, many of which have been used for hundreds of years for antisepsis, disinfection, and preservation. Despite this, less is known about the mode of action of these active agents than about antibiotics. In general, biocides have a broader spectrum of activity than antibiotics, and, while antibiotics tend to have specific intracellular targets, biocides may have multiple targets. The widespread use of antiseptic and disinfectant products has prompted some speculation on the development of microbial resistance, in particular crossresistance to antibiotics.
Chlorinated compounds are often used in dental clinics and laboratory environment due to their broad spectrum of antimicrobial activity, low toxicity, low cost and efficacy in biofilms.1 However, they corrode metals and are inactivated by organic matter at high concentrations. A slow-release chlorine compound, sodium dichloroisocyanurate is used in healthcare settings; however, it too is corrosive. Slow-release chlorine dioxide disinfectants have been developed containing corrosion inhibitors which are extensively used in the industrial settings.
The use of chlorine dioxide containing products in dentistry has been explored. Studies have shown that in mouthrinses it is effective for the management of chronic atrophic candidiasis, denture stomatitis, and the control of plaque accumulation, periodontal pathogens and oral malodor.2-5 The efficacy of sodium dichloroisocyanurate for disinfection of radiographic films and irreversible hydrocolloid impression material has also been established.6,7 none of the above studies have tested the efficacy of these disinfectants against Mycobacteria and Hepatitis B virus. In addition, anti hepatitis B virus activity of chlorine dioxide has not been established.
1.2 Statement of the problem
Chlorination of bacteria by active chlorine compounds with the aim of killing them occurs both in a variety of disinfection processes and, in vivo, in the myeloperoxidase-hypochlorite system that operates within phagolysosomes of human leuco-cytes.8–10 Investigations on the main long-lived oxidant produced by granulocytes and monocytes, N-chlorotaurine (NCT),11,12 revealed new insights in the consequences of the chlorination of pathogens. Incubation for a sublethal time of 1min in 1% NCT solution caused a lag of regrowth (postantibiotic effect) of bacteria and a loss of virulence of highly encapsulated staphylococci and streptococci, demonstrated in the mouse peritonitis model.13,14 In addition, bacteria chlorinated by the myeloperoxidase system lost their ability to induce nitric oxide and tumour necrosis factor-a in macrophages.
These findings prompted us to establish methods of detection and quantification of chlorination of bacterial surfaces and to perform the first systematic examination of chlorine covers on Gram-positive and -negative bacteria and Candida albicans.
1.3 Objectives of the study
The main objective of the study is to assess the antimicrobial properties of chlorine and alcohol disinfectants.
This study compares the antimicrobial effect of a chlorine dioxide and a chlorine generating disinfectant on the contaminants commonly present on dental instruments and in the dental surgery.
1.4 Significance/ Justifications of the study
This study will help to add to the existing knowledge in this area of research. It will be of significance in the health sector as it will reduce the effects and spread of bacteria on man. It will provide insightful information on individuals in order to educate them on the properties of chlorine and alcohol disinfectants.
This study will also help the educational sector, as it could be used as a source material to carryout further research related to this study.
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
SIMILAR MICROBIOLOGY FINAL YEAR PROJECT RESEARCH TOPICS
1. COMPARATIVE STUDY OF ANTIBACTERIAL ACTIVITY OF TWO SELECTED MEDICATED SOAP AND ONE LOCAL BLACK SOAP ON STAPHYLOCOCCUS AUREUS FROM WOUND INFECTION» ABSTRACTTwo medicated soaps and one local soap were investigated for their antibacterial activities against Staphylococcus aureus. Identification of t...Continue Reading »
2. THE DETERMINATION OF IN VITTRO ANTIBACTERIAL EFFECTS OF GARLIC (Allum sativum) AGAINST Staphylococcus aureus ISOLATED FROM BURN WOUNDS» CHAPTER ONE 1.0 INTRODUCTION 1.1 Background of the study It has been known throughout history that garlic has always been in use worldwide by various ...Continue Reading »
3. PREVALENCE OF MULTIDRUG RESISTANT LIVESTOCK ASSOCIATED STAPHYLOCOCCUS AUREUS ISOLATED FROM NASAL PASSAGE OF HEALTHY CATTLE IN KARA MARKET OGUN STATE N...» ABSTRACT Staphylococcus aureus, ‘one of the most adaptable and virulent pathogens in modern times’ is a facultative anaerobic Gram positiv...Continue Reading »
4. ISOLATION AND IDENTIFICATION OF BACTERIA FROM FOOD VENDORS AND SOME VEGETABLE AVAILABLE AT OGBETE MARKET ENUGU.» ABSTRACT Safety of food is a basic requirement of food quality. A total of 25 street food samples (Jollof rice, egwusi soup, ugu, water leaf and green...Continue Reading »
5. COMPARATIVE EVALUATION OF ANTIBODY PRODUCTION IN BROILERS VACCINATED WITH NEWCASTLE DISEASE VACCINES IN KANO METROPOLIS, NIGERIA» ABSTRACT The incidence of Newcastle disease (ND) in Nigeria is high and is a persistent cause of mortality and (or) morbidity among vaccinated chicken...Continue Reading »
6. COMPARATIVE ANALYSIS OF PIPEBORNE WATER AND OTHER SOURCES OF WATER WITHIN ENUGU METROPOLIS FOR HUMAN CONSUMPTION.(INDEPENDENCE LAYOUT LOCALITY)» ABSTRACT Comparative examination of three main sources of water supply in Independence layout Enugu was carried out with a view to determine their lev...Continue Reading »
» ABSTRACT This study was aimed at investigating the microbial load and the quality of indoor air Faith Mediplex Centre, Benin City, to ascertain their ...Continue Reading »
» CHAPTER ONE 1.0 INTRODUCTION Ugba also called ukpaka is a popular food delicacy in Nigeria especially among Ibo ethnic group. It is rich in protein an...Continue Reading »
9. CO-INFECTION OF SCHISTOSOMA HAEMATOBIUM AND ESCHERICHIA COLI IN PUPILS ATTENDING SOME SELECTED SCHOOLS IN ZARIA, NIGERIA» ABSTRACT This study was designed to investigate co infection of Schistosoma haematobium and Escherichia coli in pupils attending some selected primary...Continue Reading »
» ABSTRACT Lots of research has been conducted on Carica papaya and its antibacterial efficacy on bacterial pathogens and this led to this study on anti...Continue Reading »