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ABSTRACT
The number one killer disease in the world is Cardiovascular Disease1. The most serious element of Cardiovascular Disease is Coronary Artery Disease. Currently, the main treatment for Coronary Artery Disease is stent placement surgery. However, its long time safety and efficiency are the major setbacks, as it is associated with late restenosis and late thrombosis. These are set caused by the durable polymeric film used as the drug carrier. To improve on the current treatment (stent placement surgery), a biodegradable drug delivery system was synthesized. Paclitaxel was successfully entrapped into the polylactide-co-glycolide acids microspheres via single solvent microencapsulation evaporation method. Optical Microscopy was used to study the shape and morphology of the microspheres. The particle sizes were found to range of the microspheres is 15. 18 – 40.11µm, with a mean size of 29.415 µm, a p-value 0.986 and a z-value-0.02. The results suggest that the encapsulated drug loaded microspheres can be used as biodegradable drug eluting structures for localized vascular-targeted therapy for the treatment of coronary artery disease. This is a presented as potential alternative to stent placement surgery. The potential extensions to localized cancer treatment are also elucidated.
Chapter One
1.0 Background and Introduction
1.1 Statement of the problem (Heart Disease)
Cardiovascular disease (CVD) is caused by disorders of the heart and blood vessels, which includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), raised blood pressure (hypertension), peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure [1,2]. The first two are the major killer diseases in the whole world.
In 2002, it was estimated that 29% of deaths worldwide (16.7 million deaths) were due to CVD and that 43% of global morbidity and mortality, measured in disability-adjusted life years (DALYs), and was caused by CVD [1]. Furthermore, 78% of global mortality and 86% of mortality and morbidity from CVD occurs in developing countries.
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SIMILAR SCIENCE & ENGINEERING FINAL YEAR PROJECT RESEARCH TOPICS
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1. MEASUREMENT AND EVALUATION OF THE PERFORMANCE PROPERTIES OF SELECTED LOCALLY PRODUCED LUBRICANTS (ENGINE OIL)
» ABSTRACT The performance of the oils selected in this work was tested for considering Viscosity, Viscosity Index, Density, Flash Point, Pour Point, an...Continue Reading »Item Type & Format: Project Material - Ms Word | 99 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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2. RAIN WATER HARVESTING AS AN ALTERNATIVE TO QUALITIATIVE WATER AND AGRICULTURE IN NIGERIA
» ABSTRACT The largest environmental challenge that Nigeria is facing today is water scarcity. Current water use already exceeds renewable supply. Many ...Continue Reading »Item Type & Format: Project Material - Ms Word | 30 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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3. ASSESSING THE IMPACT OF MODERN TECHNOLOGY ON THE GROWTH OF LITHOGRAHIC PRINTING PRESSES IN KADUNA TOWN
» Abstract Printing industry among others has been affected by technological changes, most especially in the lithographic printing presses. Therefore, t...Continue Reading »Item Type & Format: Project Material - Ms Word | 45 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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4. EVALUATING THE ESSENCE OF PACKING IN SAFE GUARDING EXHIBITION ITEMS IN THE DEPARTMENT OF PRINTING TECHNOLOGY
» CHAPTER ONE 1.0 INTRODUCTION 1.1 BACKGROUND OF THE STUDY The construction industry has many features which set it apart from other industries and whic...Continue Reading »Item Type & Format: Project Material - Ms Word | 51 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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5. HEALTH AND SAFETY ON CONSTRUCTION SITE (A Case Study Of Imo State)
» ABSTRACT Building construction sites are most times very hazardous due to the bulk and types of materials and equipment employed towards the realizati...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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6. DEMONSTRATION OF HOW COUNTER CAN BE MULTIPLEX TO DO COUNTING OPERATION.
» CHAPTER ONE INTRODUCTION 1.1 BACKGROUND OF THE STUDY A digital system handles digital process and generates digital signals rather than the continuous...Continue Reading »Item Type & Format: Project Material - Ms Word | 17 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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7. THE IMPACT OF EFFECTIVE CONTRACT PLANNING ON CONTRACTORS PROFIT (A CASE STUDY OF JULIUS BERGER NIGERIA PLC, ABUJA)
» ABSTRACT Effective contract planning in construction projects is not only crucial to attainment of project objectives but necessary if project failure...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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8. BACTERIAL REMEDIATION OF POLYETHYLENE
» ABSTRACT Improper disposal of commodity plastics e.g. polyethylene (PE) in the environment causes land pollution, soil infertility, is unsightly and p...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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9. PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS
» ABSTRACT This research focuses on the design of a robust but flexible prodigiosin eluting stent coating for possible coronary cardiovascular implant. ...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT
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10. PRODUCTION AND ADORNMENT OF LEATHER ARTICLES USING LEATHER SCRAPS AND OTHER MATERIALS
» CHAPTER ONE INTRODUCTION 1.1 Background of the Study According to the modified European Directive 75/442 a solid waste is any substance or object in t...Continue Reading »Item Type & Format: Project Material - Ms Word | 105 pages | Instant Download | Chapter 1-5 | SCIENCE & ENGINEERING DEPARTMENT