The purpose of this work is to determine the biological activity and spectral analysis of Gas chromatography/mass Spectroscopy (GC-MS) profile of crude extract of S monbin,S.mombin L. (Anacardiacaea) is a plant that grows in almost every part of the world. It is fruitferious decidous plant of about 20m high that grows in the rain forest of Africa. Smombin parts were harvested early in the morning into a polythene bag. S.mombin plant (1kg) each of the different plant parts was extracted with 3 L of 70% (v/v) ethanol and ethyl acetate for 72 h at room temperature. GC-MS analysis of Ethanolic and ethyl acetate extracts of S.mombin plant was performed on a GC clarus 500 Perkin Elmer system comprising a AOC-20i auto sampler and gas chromatograph interfaced to a mass spectrometer instrument and Mass spectra were taken at 70 eV; a scan interval of 0.5 s and fragments from 40 to 550 Da. Ethyl acetate leaf extract of Spomdias mombin contained five (5) compounds, Ethanolic Stem bark extract contained three (3) compounds, Ethyl acetate root extract contained seven (7)compounds, Ethanolicroot extract of Spomdias mombin contained seven (7) compounds and Ethyl acetate stem bark extract of Spomdias mombin contained fifteen (15)compounds respectively. In this study with GC-MS analysis, thirty nine (39) compounds were elucidated  in the crude extracts of Spomdias mombin, all compoiund were used for different antimicrobial pharmacological properties. The highest number of compounds fifteen (15) was identified in the crude ethyl acetate stem bark of Spomdias mombin

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