Get the complete project »
- The Complete Research Material is averagely 52 pages long and it is in Ms Word Format, it has 1-5 Chapters.
- Major Attributes are Abstract, All Chapters, Figures, Appendix, References.
- Study Level: BTech, BSc, BEng, BA, HND, ND or NCE.
- Full Access Fee: ₦4,000
The effects of vitamin C on some heamatological parameters and biomarkers of oxidative stress in albino wistar rats exposed to lead acetate over a short term (3 weeks) was investigated. Studies have revealed that lead has a wide range of health effects that can result from exposure, and that lead can cause health effects at blood lead levels previously thought to be safe. An increasing body of evidence suggests that lead is associated with a number of health conditions. Twenty albino wistar rats were randomly divided into four experimental groups of five rats each, Control group were fed normal rat feed with distilled water, Group 2,3 and 4 were fed normal rat feed, water and received daily oral administration of lead acetate 250mg/kg daily. In addition groups 3 and 4 received 100mg/kg and 150mg/kg oral administration of vitamin C respectively, for three weeks. Mild effect of lead acetate was observed in haematological parameters as indicated by slightly increase ,which was not statistically signifiant, in RBC and MPV. In contrast, a slight decrease was seen in haemoglobin, PCV, MCV, MCH, MCHC and platelet count. Descrease in MCV,MCH and MCHC indicated shrink in size of RBCs and onset of microcytic anemia due to onset of iron deficiency. However, derease observed was not stgatistically signifiant. Also the effect of lead acetate was mild on biochemical enzyme activities, indicated byincreased level of MDA activity; whih indicate oxidative stress,however the increase was not statistically significant. SOD and GPx level were slightly decreased, which was not statistially signifiant. The doses of vitamin C supplement did not reverse the effect of lead acetate on some haematological parameters and some biochemical enzyme activities, it however reverse the effect of lead acetate on MDA level. In conclusion, exposure to lead acetate over a short term has little effect on haematological parameters and biochemical enzyme activities. The doses of vitamin C use in this study has ameliorative effect on MDA activity but has no effect on some alteration on haematological parameters and some biochemical enzyme activities.
1.1 GENERAL INTRODUCTION
Lead is a naturally occurring bluish-gray heavy metal found in small amounts in the earth‟s crust.
However, it is rarely found naturally as a metal. It is usually found combined with two or more other elements to form lead compounds (ATSDR, 2007). Metallic lead is resistant to corrosion (i.e., not easily attacked by air or water). When exposed to air or water, thin films of lead compounds are formed that protect the metal from further attack (ATSDR, 2007). Lead is poisonous when inhaled or eaten. Lead content in air, food and tap water has increased several folds during recent years due to extensive use of this metal in petrol, paints, battery and other industries (Tuarmaa, 1995). According to WHO (2000) lead is a metal with no known biological benefit to humans. Too much lead can damage various systems of the body including the nervous and reproductive systems and the kidney.
Generally, heavy metals produce their toxicity by forming complexes or ligands with organic compounds thereby affecting the function of biological molecules, inactivate some biochemical enzymes and affect protein structure (Pirkle, 1998) Because of its potential health problems, the amount of lead used in these products today has lessened or has been removed. Lead and other heavy metals create reactive radicals which damage cell structure including DNA and cell membrane (Flora, 2008). Lead poisoning can cause a variety of symptoms and signs which vary depending on the individual and the duration of lead exposure (Kosnett, 2005, Karri, 2008 ).
The amount of lead in blood and tissues, as well as the time course of exposure, determines the level of toxicity (Pearson and Schonfeld, 2003).
You either get what you want or your money back. T&C Apply
You can find more project topics easily, just search
SIMILAR ENGLISH LITERARY STUDIES FINAL YEAR PROJECT RESEARCH TOPICS
1. A SOCIO LINGUISTIC ANALYSIS OF THE USE OF DEROGATORY WORDS ON WOMEN (A CASE STUDY OF IKEJA LOCAL GOVERNMENT AREA OF LAGOS STATE)» CHAPTER ONE INTRODUCTION BACKGROUND OF THE STUDY Sociolinguistics cannot be defined without the language use and the society’s feedback to it. S...Continue Reading »
» CHAPTER ONE GENERAL INTRODUCTION 1.1 Background of the Study Language is an important tool in the entire existence of man, because it aids communicati...Continue Reading »
3. DRAMATIZATION OF NORTHERN NIGERIAN HISTORY: [ADAPTATION, TRADITION AND PERSONAGES] OF BEN TOMOLOJU’S AMINATU QUEEN OF ZAZZAU, AHMED YERIMA’S ATTAH...» ABSTRACT This thesis examines the interplay between the adaptation of historical materials for dramatic purpose and the production of what may be refe...Continue Reading »
» ABSTRACT This work studied the discourse analysis of Athol Fugard’sSizweBansi is Dead. The encoded meaning in the conversational exchange among ...Continue Reading »
5. A SYNTACTIC ANALYSIS OF SELECTED CLAUSAL COORDINATES AS USED IN THE AMENDED 1999 CONSTITUTION OF THE FEDERAL REPUBLIC OF NIGERIA» ABSTRACT The language of law has been viewed by many as difficult to understand primarily because of archaism in its morpho syntactic structure. Also,...Continue Reading »
6. STRATEGIES FOR IMPROVING LOW ACADEMIC PERFORMANCE IN ENGLISH LANGUAGE IN SECONDARY SCHOOLS IN KADUNA STATE (A CASE STUDY OF SOME SELECTED SECONDARY SC...» ABSTRACT This study examines strategies for improving low academic performance in English language in secondary schools in Kaduna state. Over the year...Continue Reading »
7. PRAGMATIC ANALYSIS OF OLISA METUH'S DYSPHEMISMS AGAINST PRESIDENT MUHAMMADUBUHARI'S ADMINISTRATION» CHAPTER ONE Introduction 1.1 Background to the study Varied researches on the use of language has made language users understand the fact that there i...Continue Reading »
8. THE LANGUAGE OF FEMINISM AND ITS IMPACT ON THE SOCIETY USING THE WORK OF MARIAMA BA’S SO LONG A LETTER» CHAPTER ONEINTRODUCTIONBackground of Study The struggle for women’ right began in the 18th century during the period of intense intellectual activit...Continue Reading »
» ABSTRACT Existing studies in different spheres of human endeavour have focused on the negative and destructive potentials of conflict. The scanty atte...Continue Reading »
» CHAPTER ONE GENERAL INTRODUCTION 1.1 Introduction Feminism is an ideology, movement whereby people (both male and female) agitate for equality between...Continue Reading »