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Abstract
The evaluation of makers for characterized underlined pathologies in diabetes mellitus
isuseful in prevention, monitoring and management of the disease. This studyaimed to
investigate the effects of clove buds and fermented ginger rhizome supplements
onblood glucose, insulin, insulin receptor, leptin levels, Lipid profile, thyroid
hormones, thyroid stimulating hormone (TSH) concentrations, oxidative stress and
lipid peroxidation biomarkers, liver enzymes and electrolytes levels in high fat diet
(HFD) induced type 2 diabetes(T2DM) in rabbits. Thirty male rabbits (8-10 weeks of
age) divided into six groups (n=5) were used for the study. Type 2 diabetes was
induced by feeding rabbits with a HFD (standard animal feed (SAF) 69% + Cholesterol
1% + Groundnut mill 20% + ground nut oil 10%) for 11 weeks, and animals with
blood glucose levels≥ 140 mg/dL were selected as type 2 diabetes animal model
(DAM). They were then subjected to experimental protocol and treatments for six
weeks as follows.Group I, normal rabbits fed on SAF only (Normal control); Group II,
DAM fed on SAF only also(Diabetic control); Group III, DAM fed on SAF +
cholestran (0.26 g/kg); Group IV, DAM fed on SAF with clove (12.5%); Group V,
DAM fed on SAF with fermented ginger (12.5%) and Group VI, DAM fed on SAF
with clove (12.5%) + fermented ginger (12.5%) supplements.Blood glucose was
assessedweekly, at the end of six weeks treatments, animals were anesthetized,blood
samples were collected via cardiac puncture and the serum was usedfor biochemical
assessments. The results revealed a significant(P<0.05) decrease in blood glucose level
at first and fourth week of treatment in all supplement treated groups,adecrease was
also noted at fifth week in the clove supplements treated group when compared to the
level in diabetic control group. There was also asignificant (P<0.05) increase in insulin
levels in all DAM groups when compared to normal control group, while leptin
vii
levelssignificantly decreased in clove supplement treated group when compared to the
diabetic control group. Triglycerol (TG)level significantly decreased in DAM group
treatedwith fermented ginger when compared to diabetic control.Thyroid hormones,
triiodothyronine (T3) and thyroxine (T4) levels significantly decreased in supplement
treated groups compared to diabetic control group.The oxidative stress makers,
superoxide dismutase (SOD)was significantly increased in DAM group treated on
clove + fermented ginger, while catalase (CAT) and (GPx)were significantly increased
in the supplement treated groups compared to thediabetic control
group.Alsomalondialdehyde (MDA) levelwas significantly decreased in DAM fed on
fermented ginger supplement and in the combined supplements(clove + fermented
ginger) treated groupscompared to the diabetic control group.Liver enzymes (ALT,
AST and ALP)activitieswere significantlydecreased in supplement treatedgroups
compared to their levels in diabetic control group. Serum Na+ level
wassignificantlyincreased in DAM groups treated on clove (12.5%) and that treated
with fermented ginger (12.5%), compared to that of diabetic control group, while K+
level wassignificantlydecreased in all supplement treated groups. Bicarbonate ions
were increased in clove supplement treated group compared to that of diabetic control.
The findings of the present study shows that,supplementation of clove, fermented
ginger and their combinationto HFD-induced diabetic rabbits; have hypoglycaemic,
hypolipidaemic, antioxidant, hepato-protective and electrolytes normalization activity.
This indicate a pronounced ameliorative effectof the studied supplements onthe
metabolic derangement observed in HFD-induced diabetic rabbits.Hence, these
supplementsshould be considered, amongvalued dietary supplementsintended
forrestoration/correction of altered physiological parametersin related condition.
CHAPTER ONE
1.0 INTRODUCTION
1.1 Background of the Study
Diabetes mellitus (DM) is among the fastest-growing health problem in the World,
with a rising prevalence in low andmiddle-income countries than in high-income
countries over the past decade. In the present day, DM is reaching epidemic proportion
in some regions, as a consequence of interaction between change in life-style (lack of
exercise, unhealthy diet), obesity,overweight, and individuals‘ genetic make-up (World
Health Organization (WHO), 2016). DM is among the common chronicnon-
communicable disease in many populations at present, associated with risk factors that
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