EFFECT OF OMEGA 3 FATTY ACIDS AND VITAMIN A ON CARRAGEENAN INDUCED JOINT INFLAMMATION IN FEMALE WISTAR RATS

EFFECT OF OMEGA 3 FATTY ACIDS AND VITAMIN A ON CARRAGEENAN INDUCED JOINT INFLAMMATION IN FEMALE WISTAR RATS

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Abstract

Joint inflammation is a hallmark of diseases such as arthritis affecting single or multiple joints

associated with increased pro-inflammatory markers and free radicals. Efforts are channeled

towards discovering therapeutic agents which are more effective, less toxic with prolonged use

and more affordable.The aim of this study was to investigate the effect of omega 3 fatty acids

and vitamin A supplements on knee circumference, TNF-α, C-reactive protein (CRP), oxidative

stress biomarkers: superoxide dismutase (SOD), glutathione (GSH), catalase (CAT) and

malondialdehyde (MDA) on carrageenan-induced joint inflammation in female Wistar

rats.Twenty four female Wistar rats of age 10 weeks weighing between 150-200g divided into

six groups of 4 animals each were used for the study.Group 1 (normal control), group 2

(injection control [normal saline]), group 3-6 received 0.02ml of 1% CGN injection 3x/week for

10 weeks but in groups 4-6, after first 2 weeks of CGN injection, oral treatment with 200mg/kg

Omg3, 4000IU/kg VA and 200mg/kg Omg3+4000IU/kg VA respectively was given daily with

simultaneous injection of the CGN for the remaining 8 weeks. Knee diameter was measured

before the first injection (at day 0), at week 2 and t


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