EFFECT OF Cola nitida (COLANUT) ON GASTROINTESTINAL MOTILITY OF ULCER INDUCED WISTAR RATS

EFFECT OF Cola nitida (COLANUT) ON GASTROINTESTINAL MOTILITY OF ULCER INDUCED WISTAR RATS

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ABSTRACT

The effect of the ethanolic extract of Cola nitida (colanut) on the intestinal motility, gastric secretion and ulceration in albino wistar rats was studied. Acute toxicity of the plant was carried out using Lorke’s method. 27 mice were used for this study. The mice were divided into 9 groups of 3 animals each. The group administered 1000mg/kg of the plant extract recorded 0% mortality while the groups taking 1250-5000mg/kg of the extract recorded 100% mortality. LD50 was calculated based on this as 1118.03mg/kg. Thirty albino wistar rats were weighed and divided into eight groups. Group 1 with three animals served as the control and was administered 10ml/kg of distilled water. Group 2 with 3 animals served as the control induced with ulcer and was administered 10ml/kg of distilled water. Groups 3-5 with four animals each were administered low dose (111.80mg/kg), medium dose (223.61mg/kg) and high dose (335.41mg/kg) of the C. nitida extract respectively. Group 6 was administered medium dose of the extract + omeprazole, group 7 was medium dose of the extract + ranitidine and group 8 was administered medium dose of the extract + cimetidine according to their body weight daily for 14 days. Intestinal motility was determined at the end of the 14days and the basal height of contraction was significantly (p<0.05) higher in the extract group as compared to the control. On gastric secretion, there was a dose dependent in the groups administered the extract as compared to the control. On ulceration, there was a significant increase in ulceration in the groups administered the extract as compared to the control group. It can thus be concluded that Cola nitida (colanut) increases intestinal motility, gastric secretion and ulceration. Therefore, it should be taken with caution in individual with peptic ulcer and can be used in the treatment of gastric motility disorder.


CHAPTER ONE

INTRODUCTION

 

 

1.1 Background of the study

 Cola nitida, popularly known as colanut is a caffeine containing nut. It is widely distributed in Africa and the sub-Saharan region. They are widely cultivated in West Africa and are used to counteract fatigue, suppress thirst and hunger and are believed to enhance intellectual activity (Nickalls, 1986, Sundstrom, 1966). It has also been used in folk medicine as an aphrodisiac, as an appetite suppressant, to treat morning sickness, migraine headache and indigestion (Esimone et al., 2007). Cola nitida is of the Cola genus and is closely related to another specie of the Cola family, Cola acuminata. Cola acuminata is more popular in the Igbo and Igedde tribes of the eastern and middle regions of Nigeria, while cola nitida is more common in the northern part of the country among the Hausa and Fulani (Ibu et al., 1986). It is often offered traditionally in many Nigerian customs as a sign of hospitality. The twigs are also used as ‘chewing sticks’ for cleaning the teeth and gums.

Medicinally, the leaves, bark and other parts of the plant are used to prepare a tonic for the treatment of dysentery, cough, vomiting and diarrhea (Ayensu, 1978). It is also directly applied to wounds to enhance the healing process and to treat inflammation (Newal et al., 1996).

1.2 Statement of Research Problem

Duodenal and peptic ulcers are common in the southern part of Africa, Rwanda, Burundi and Eastern Zaire, highlands of Ethiopia, Central Sudan and East Africa especially around Mountain Kilimanjaro (Tende et al., 2011). Cola nitida has a high concentration of caffeine, even higher than that contained in coffee (Moloney, 1887). C. nitida is readily consumed generally in Nigeria and in parts of Africa for medicinal, cultural and traditional purposes. This study is undertaken to investigate the effect of C. nitida on the healing process of ulcer and its effect on gastric motility.

1.3 Aims and Objectives of the Study

The aim of this study was to:

(a)  Investigate the effect of Cola nitida extract on the healing process of albino wister rats undergoing antiulcerogenic treatment with cimetidine, ranitidine and omeprazole.

(b) Investigate the effect of cola nitida extract on gastrointestinal motility

 

 

 

1.4 Significance of the Study

This study is to evaluate the effect of cola nitida extract on albino wistar rats undergoing treatment with known antiulcerogenic drugs.  The outcome of this study will enable consumers of cola nitida to know its effect on gastrointestinal motility. Findings from this study will also provide the scientific community, medical practitioners, pharmacists, nutritionists and the general public information on the possibility of cola nitida consumption affecting ulcer treatment.

1.5 Scope and Limitation of the Study

This research work covers the effect of cola nitida extract on gastric motility of ulcer-induced albino wistar rats and its effect on the healing process but is limited to the effect of cola nitida extract on gastrointestinal motility in ulcer.

1.6 Justification of Study

Literature studies have shown that consumption of cola nitida increases gastric secretion. This research is therefore essential to determine if increased consumption of cola nitida will affect ulceration and gastrointestinal motility.


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