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ABSTRACT
Kola bark extract have been widely used in tradition medicine for
thousand of year, it improves liver functions and provides protection
against high fat fed metabolic rats. Present investigations were carried
out on the hepatoprotective role of Kola bark extract meal treatment to
high fat fed wistar rat. Healthy adult male wistar rats were divided
into four groups Group I: rats were fed a standard Laboratory diet
(groups match) (20g/rat/day), Group II: rats were fed a high-fat diet
alone (3.6g/rat/day), Group III: rats were fed with combined mixture of
70% of high-fat diet with 30% Kola bark meal (9.8g/rat /day), Group/ V:
rats were fed with high fat diet and was administered with Lipitor
(Atovastatin) (10mg/rat/day) . The rats were sacrificed at the end of
the experiment (two weeks) period. The high fat fed rat substantially
elevated its serum and liver tissue AST, ALT, ALP, bilirubin with
decreased in total protein levels. Where as the levels of all parameters
significantly restored towards normalization by the kola bark husk meal
treatment. The results obtained suggest that the Kola bark meal have
potent hepatoprotective action on high fat fed rats. A companion of the
performance in both Kola bark meal and Lipitor treatment on high fat fed
rat in respect of hepatoprotective role is clearly indicator that the
Kola bark meal treatment was more and related to the result of Lipitor
as well as to the normal level.
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