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ABSTRACT
Crateva adansonii is a medicinal herb commonly used in parts of Africa becauseof the side effects of Non-Steroidal Anti-inflammatory Drugs (NSAID), like heart diseases and kidney failure. Inflammation is a major public heart issue in the world but treatment is becoming complex because of the side effects of anti-inflammatory pharmaceutical drugs. Hence the need for alternative drug is highly required. This research work investigated the anti-inflammatory activity of dichloromethane fraction of methanol extract of Crateva adansonii stem bark, using rodent model. Adult Swiss albino rats (110-200g) of either sex were randomlydivided into 5 groups of 4 animals each. Groups 2, 3, 4, and 5 received different doses of the extract (300mg, 500mg, 700mg, and 900mg) in 3% v/v tween 80 administered intraperitonally respectively. Control group-1 received volume of 3%v/v tween 80 and standards group received 100mg/kg Ibuprofen. One hour later acute inflammation was induced by injection of 0.1ml of undiluted egg albumin into the sub planter of the right hand paw of rats. The volume of the paw was measured by mercury displacement before and at 0.5, 1, 1.5, 2, 2.5 & 3 hours after egg albumin injection, while the standard was measured at internals of one hour, for up to 4 hours. Edema formation was assessed in terms of the difference in the zero time per volume of the injected pair and its volume at the different time after egg albumin injection. For each dose of extract, percentage inhibition of edema was calculated percentage inhibition. Result show that Crateva adansonii may have anti-inflammatory effects. This finding supports the use stembark of Crateva adansonii in not only traditional medicine for the treatment of inflammation.
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SIMILAR BIOCHEMISTRY FINAL YEAR PROJECT RESEARCH TOPICS
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1. Effect of some Africa medicinal plants extracts with antitrypanosomal activity.
» CHAPTER ONE 1.0 INTRODUCTION 1.1 BACKGROUND OF STUDY Most of traditional medicines are of plant origins. Nature has gifted us with so many medic...Continue Reading »Item Type & Format: Project Material - Ms Word | 53 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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2. EXTRACTION, CHARACTERIZATION AND ANTI-MICROBIAL SCREENING OF WHITE STAR APPLE Crysophyllum albidum SEED OIL
» ABSTRACT Crysophylum albidum oil was extracted from its seed. The percentage yield was 2.56%. The characterization of the oil showed showed that the r...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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3. EFFECTS OF ETHANOL, METHANOL AND N-HEXANE LEAF AND FRUIT EXTRACTS OF Kigelia africana ON SOME OXIDATIVE AND BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED ...
» ABSTRACT Globally, the estimated incidence of diabetes and projection for the year 2030 as given by the International Diabetes Federation (IDF) is 350...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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4. EVALUATION OF INHIBITORY EFFECTS OF KHAYA SENEGALENSIS AND VERNONIA AMYGDALINA EXTRACTS AGAINST SOME BACTERIA ISOLATED FROM POULTRY DROPPINGS
» ABSTRACT Recent studies have incriminated the use of antibiotics in poultry feeds to be associated with emergence of resistance among bacteria. The us...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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5. CARDIO PROTECTIVE ACTIVITIES OF N-HEXANE EXTRACT OF DESMODIUM VELUTINUM STEM ON ALBINO WISTER RAT
» ABSTRACT This study evaluates the effect of the cardio protective N hexane extract of Desmodium stem velutinum on wister albino rat. The rats used in ...Continue Reading »Item Type & Format: Project Material - Ms Word | 50 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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6. COMPREHENSIVE THEORETICAL COMPARATIVE STUDY ON CUBIC AND MONOCLINIC LATTICE OF WO3 USING DFT AS IMPLEMENTED IN QUANTUM ESPRESSO
» CHAPTER ONE 1.0 INTRODUCTION Tungsten (vi) oxide, also known as tungsten trioxide or tungsten analysis, W03 is a chemical com...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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7. ALTERATION OF SIALIC ACID LEVELS DURING PLASMODIUM FALCIPARUM INFECTION IN HUMANS
» Abstract Malaria is still a major disease that causes millions of deaths, mostly among children under five years old and pregnant women, in tropical c...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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8. AMELIORATING ROLE OF N.P.K. FERTILIZER ON THE TOXIC EFFECTS OF Ni ON (SORGHUM) ROOT ANTIOXIDANT ENZYMES
» ABSTRACT This study investigated the activities of superoxide dismutase (SOD), catalase (CAT), glutothione peroxidase (GP) and the level of malondiald...Continue Reading »Item Type & Format: Project Material - Ms Word | 52 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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9. EFFECTS OF ETHANOL ROOTS EXTRACT OF UGU OYIBO (Jatropha tanjorensis) ON HAEMATOLOGICAL INDICES OF FEMALE ALBINO WISTAR RATS
» ABSTRACT Jatropha tanjorensis is a natural medicinal herb which has been used over the years in the treatment of many health disorders. This study was...Continue Reading »Item Type & Format: Project Material - Ms Word | 82 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT
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10. BIODIESEL AS ALTERNATE SOURCE OF ENERGY
» INTRODUCTION 1.0 GENERAL INTRODUCTION Energy is a fundamental pillar of modern society as well as being an essential building block for socio economic...Continue Reading »Item Type & Format: Project Material - Ms Word | 41 pages | Instant Download | Chapter 1-5 | BIOCHEMISTRY DEPARTMENT